Results 141 to 150 of about 599,745 (242)

Novel Roles of GPCRs in the Renal Collecting Duct. [PDF]

Physiology (Bethesda)
Kui MK, Zhang JJ, Pluznick JL.
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Nectin-4 and Trop-2 expression in collecting duct carcinoma: new promising therapeutic targets. [PDF]

ESMO Open
Rametta A, Stellato M, Rota S, Gusmaroli E, Huber V, Gobbo S, Pedron S, Colombo P, Caliò A, Martignoni G, de Braud F, Procopio G, Brunelli M, Verzoni E.   +13 more
europepmc   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Multiple Retransplantations After BK Polyomavirus-Associated Metastatic Collecting Duct Carcinoma: Evidence for Protective BK-specific T-Cell Immunity. [PDF]

Transplantation
Hammer N, Khanna N, Haidar F, Hirsch HH.
europepmc   +1 more source

A Rare Case of Collecting Duct Carcinoma With Extensive Coagulative Necrosis. [PDF]

Cureus, 2023
Colef R, Mescallado L, Kiran N, Wrzolek M, Khan S.   +4 more
europepmc   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Effects of proximal tubule NBCe1-A deletion on collecting duct intercalated cell responses to hypokalemia. [PDF]

Am J Physiol Renal Physiol
Lee HW, Harris AN, Wall SM, Weiner ID.
europepmc   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Rare renal tumor: a case report of collecting duct carcinoma and literature review. [PDF]

Front Oncol
Zhu C, Zhang Y, Tian Z, Yang T, Han G, Luo H, Yu B, Zhang N, Fu N.   +8 more
europepmc   +1 more source