Results 161 to 170 of about 599,745 (242)

Avelumab in metastatic collecting duct carcinoma of the kidney: a case report. [PDF]

J Med Case Rep, 2023
Pyrgidis N, Sokolakis I, Haltmair G, Heller V, Hatzichristodoulou G.   +4 more
europepmc   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Depletion of renal cortical collecting duct-secreted PCSK9 in early proteinuria prevents sustained nephrotic syndrome-related hypercholesterolemia. [PDF]

Am J Physiol Renal Physiol
Molina-Jijon E, Zavala-Guevara IP, Gambut S, Gomez-Sierra T, Avila-Casado C, Macé C, Clement LC.   +6 more
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Hypertonicity-induced RNF183 targets NKCC1 to protect kidney collecting duct cells but induces apoptosis in colon cells. [PDF]

Commun Biol
Okamoto T, Higashi Y, Takemoto M, Matsuhisa K, Sato S, Saito A, Omura I, Kamikawa Y, Imaizumi K, Kaneko M.   +9 more
europepmc   +1 more source

Collecting duct renin regulates potassium homeostasis in mice. [PDF]

Acta Physiol (Oxf), 2023
Xu C, Chen Y, Ramkumar N, Zou CJ, Sigmund CD, Yang T.   +5 more
europepmc   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Collecting duct carcinoma with retroperitoneal mass as initial presentation: a rare case report. [PDF]

BMC Urol, 2023
Ye R, Liao Y, Xia T, Zhang X, Lu Q, Xiao X.   +5 more
europepmc   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Proteogenomic Analysis Identifies Clinically Relevant Subgroups of Collecting Duct Carcinoma. [PDF]

Research (Wash D C)
Qu Y, Pei X, Feng J, Yan X, Zhang L, Wang J, Yao X, Bian J, Gan Y, Gan H, Jiang X, Yang P, Cai M, Li L, Wu X, Jing W, Zhang C, Zhao J, Zhang H, Shi G, Zhou X, Ye D, Ding C.   +22 more
europepmc   +1 more source