Results 181 to 190 of about 599,745 (242)

Good response with nivolumab and cabozantinib combination therapy in patients with metastatic collecting duct carcinoma with high expression of PD-L1, c-MET, and AXL. [PDF]

CEN Case Rep
Umemoto T, Hasegawa M, Naruse J, Kano T, Nakajima N, Nitta M, Kawamura Y, Kajiwara H, Shoji S.   +8 more
europepmc   +1 more source

Generation of Atp6v1g3-Cre mice for investigation of intercalated cells and the collecting duct.

Am J Physiol Renal Physiol, 2023
Saxena V, Arregui S, Zhang S, Canas J, Qin X, Hains DS, Schwaderer AL.   +6 more
europepmc   +1 more source

A Neutrophil Membrane‐Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age‐Dependent Perioperative Neurocognitive Disorders

Advanced Science, EarlyView.
This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang, Jiahui Cheng, Huan Xu, Qiang Zhang, Xiao Zhang, Ye Liu, Yizhe Zhang, Wanbing Dai, Zhi Xiong, Linghuan Guo, Lingling Xu, Wen Wang, Xin Xu, Yan Zhou, Weifeng Yu, Bo Li, Diansan Su, Daxiang Wen   +17 more
wiley   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations. [PDF]

Dis Model Mech
Mungara P, MacNaughton K, Ullah AKMS, Essuman G, Chelangarimiyandoab F, Mumtaz R, Hennings JC, Hübner CA, Eladari D, Alexander RT, Cordat E.   +10 more
europepmc   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Comprehensive molecular characterization of collecting duct carcinoma for therapeutic vulnerability. [PDF]

EMBO Mol Med
Guan P, Chen J, Mo C, Fukawa T, Zhang C, Cai X, Li M, Hong JH, Chan JY, Ng CCY, Lee JY, Wong SF, Liu W, Zeng X, Wang P, Xiao R, Rajasegaran V, Myint SS, Lim AMS, Yeong JPS, Tan PH, Ong CK, Xu T, Du Y, Bai F, Yao X, Teh BT, Tan J.   +27 more
europepmc   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Field‐Driven Active Colloids as Distributed Micromachines: Bridging Physics, Control, and Function Across Length Scales

Advanced Science, EarlyView.
Field‐driven active colloids are framed as distributed micromachines in which externally supplied power, sensing, and control regulate task‐relevant states. By closing the loop between particle behavior, imaging, computation, and electric or magnetic actuation, these systems can progress from programmable motion toward adaptive functional outcomes ...
Ruchi Patel, Bhuvnesh Bharti
wiley   +1 more source

Surgery lengthens survival for collecting duct carcinoma: analysis of hospital-based cancer registry data in Japan. [PDF]

BMC Cancer
Kandori S, Suzuki S, Kojo K, Isoda B, Tanaka T, Nitta S, Shiga M, Nagumo Y, Ikeda A, Kawahara T, Hoshi A, Negoro H, Mathis BJ, Okuyama A, Nishiyama H.   +14 more
europepmc   +1 more source