Results 231 to 240 of about 105,733 (289)

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Urothelial Carcinoma of the Renal Pelvis with Synchronous Ipsilateral Collecting Duct Carcinoma: Two Case Reports. [PDF]

J Korean Soc Radiol
Bae SB, Yoon SK, Rha SH.
europepmc   +1 more source

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

Kidney collecting duct-derived vasopressin is not essential for appropriate concentration or dilution of urine.

Am J Physiol Renal Physiol
Zuchowski Y, Carty JS, Trapani JB, Watts JA, Bock F, Zhang M, Terker AS, Zent R, Delpire E, Harris RC, Arroyo JP.   +10 more
europepmc   +1 more source

Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry. [PDF]

Sci Adv
Bock F, Dong X, Li S, Viquez OM, Sha E, Tantengco M, Hennen EM, Plosa E, Ramezani A, Brown KL, Whang YM, Terker AS, Arroyo JP, Harrison DG, Fogo A, Brakebusch CH, Pozzi A, Zent R.   +17 more
europepmc   +1 more source

Advanced Investigation of the Elimination of Methylene Blue From Wastewater Using Activated Carbon–Copper Oxide Nanowires: New Perspectives With Statistical Physical Modeling

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT In this study, the actual route of methylene blue (MB) dye adsorption by using fabricated polyfunctional activated carbon–copper oxide nanowires (AC@CuO‐NWs) from bulky wastewater bodies has been investigated. To better understand the exact pathway of the adsorption process, a prominent statistical physics formalism or grand canonical ...
Abdellatif Sakly, Nizar Lefi, Mohamed Bouzid, Salah Knani, Md. Mahmudur Rahman, Besma Graba, Sivarama Krishna Lakkaboyana, Abdelmottaleb Ben Lamine   +7 more
wiley   +1 more source

Thermal Calculations for Co‐Firing of Hydrogen/Ammonia and Coal in 660‐MW Coal‐Fired Boilers

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT To achieve a clean energy transition under the dual carbon goals, blending hydrogen/ammonia into pulverized coal boilers represents a key technological pathway. Different hydrogen/ammonia co‐firing ratios (5%–50%) are investigated for their impact on the thermodynamic characteristics of 660‐MW supercritical boiler at 100% and 20% boiler ...
Yaodong Da, Nana Hou, Weipeng Wang, Yongqiang Chang, Xin Liu, Feng Pan, Defu Che, Lei Deng   +7 more
wiley   +1 more source

The morphology of the oval window in Paranthropus robustus compared to humans and other modern primates

The Anatomical Record, EarlyView.
Abstract The oval window (OW) is an opening connecting the inner and middle ear. Its area has been shown to consistently scale with body mass (BM) in primates, and has been used alongside semi‐circular canal (SCC) size to differentiate Homo sapiens and fossil hominins, including Paranthropus robustus.
Ruy Fernandez, José Braga
wiley   +1 more source

A perspective from the Mesozoic: Evolutionary changes of the mammalian skull and their influence on feeding efficiency and high‐frequency hearing

The Anatomical Record, EarlyView.
Abstract The complex evolutionary history behind modern mammalian chewing performance and hearing function is a result of several changes in the entire skeletomuscular system of the skull and lower jaw. Lately, exciting multifunctional 3D analytical methods and kinematic simulations of feeding functions in both modern and fossil mammals and their ...
Julia A. Schultz
wiley   +1 more source

Vasopressin V2 receptor, tolvaptan, and ERK1/2 phosphorylation in the renal collecting duct.

Am J Physiol Renal Physiol
Khan S, Raghuram V, Chen L, Chou CL, Yang CR, Khundmiri SJ, Knepper MA.   +6 more
europepmc   +1 more source