Results 131 to 140 of about 9,179 (227)

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Surgery lengthens survival for collecting duct carcinoma: analysis of hospital-based cancer registry data in Japan. [PDF]

BMC Cancer
Kandori S, Suzuki S, Kojo K, Isoda B, Tanaka T, Nitta S, Shiga M, Nagumo Y, Ikeda A, Kawahara T, Hoshi A, Negoro H, Mathis BJ, Okuyama A, Nishiyama H.   +14 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Comparative Outcomes of Fine Needle Aspiration and Core Needle Biopsy for Parotid Masses

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To compare the diagnostic accuracy and safety of ultrasound‐guided fine needle aspiration (FNA) versus core needle biopsy (CNB) for parotid masses. Study Design Retrospective cohort study. Setting Tertiary academic medical center, 2018 to 2023. Methods We reviewed 485 patients undergoing ultrasound‐guided parotid biopsy (426 FNAs and
Lisa Eleni Chionis Buhler, Andrew Prince, Nicholas Bunda, Kimberly Oslin, Joshua Smith, Michael Allevato, Emma Hershey, Steven B. Chinn, Mark E. P. Prince   +8 more
wiley   +1 more source

Effective treatment of collecting duct carcinoma in a recipient of a kidney transplant: A case report. [PDF]

Oncol Lett
Nascimento de Assis TCF, Rapatoni L, Segato FN, Maciel Pontes BT, Muglia VF, Neto MM, Almeida Romao E.   +6 more
europepmc   +1 more source

Complications of Cochlear Implant Surgery in Low‐ and Middle‐Income Countries: A Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Hearing loss disproportionately affects low‐ and middle‐income countries (LMICs). Recent advances in cochlear implant surgery have benefitted patients globally, but the risk of complications in LMICs may be heightened due to social and structural factors.
Akash Srinivasan, Anavi Prakash, Wing K. Chou, Kat Steiner, Kokila Lakhoo   +4 more
wiley   +1 more source

Metabolic parameters analysis of ¹⁸F-FDG PET/CT in the diagnosis and differential diagnosis of collecting duct carcinoma. [PDF]

Am J Nucl Med Mol Imaging
Qiu Y, Zhang X, Cheng J, Huang W, Chen Z, Song L, Yang Q, Sun X, Wang A, Wang T, Kang L.   +10 more
europepmc   +1 more source

A Protocol for Reconstructing Complex Lateral Skull Base Defects: Two Decades of Tertiary Care Experience

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To describe a multidisciplinary protocol for the resection and reconstruction of complex lateral skull base pathology, based on over two decades of experience in a high‐volume tertiary referral center in the United Kingdom. Study Design Retrospective descriptive analysis of institutional practice. Setting A high‐volume tertiary skull
Muhammad Umar Farooq, Yuri Hirayama, Jameel Muzaffar, Raghu Kumar, Charlie Huins, Peter Monksfield, James Baden, Demetrius Evriviades, Richard Irving   +8 more
wiley   +1 more source

Ultrasonographic Features of Spiradenomas and Cylindromas as Diagnostic Clues in the Pre‐Therapeutic Setting

JEADV Clinical Practice, EarlyView.
Diana Crisan, Tina Weiss, Karin Scharffetter‐Kochanek, Yusef Sallum, Ioana‐Ancuta Ungureanu, Maria Crisan   +5 more
wiley   +1 more source

2025 American Thyroid Association Management Guidelines for Adult Patients With Differentiated Thyroid Cancer: What's New for Surgeons?

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract The American Thyroid Association (ATA) has published an update to the 2015 management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer (DTC). This updated version focuses solely on the management of differentiated thyroid cancer, offering a comprehensive set of guidelines for all stakeholders in the care of ...
Chau Nguyen, Amanda Silver Karcioglu, Joseph Scharpf   +2 more
wiley   +1 more source