Results 211 to 220 of about 15,464,746 (377)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Co-creating health system innovation with people who use drugs. [PDF]

Harm Reduct J
McBeth R, Sandberg C, Varewny V, Piggott B, Ajani A, Auger S, Campbell-Scherer D, Dong K, Hyshka E, Srinivasan C, Twan S, Umpherville L, Salvalaggio G.   +12 more
europepmc   +1 more source

List of the specimens of Mammalia in the collection of the British museum

John Gray
openalex   +2 more sources

I. Collections in foreign geology.—[No. I.] [PDF]

Henry T. De la Beche
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Global sampling decline erodes science potential of natural history collections. [PDF]

Nat Commun
Forbes O, Young AG, Thrall PH.
europepmc   +1 more source

Catalogue of the crustacea brought by Thomas Nuttall and J.K. Townsend from the west coast of North America and the Sandwich Islands, with descriptions of such species as are apparently new, among which are included several species of different localities, previously existing in the collection of the Academy /

J.W. Randall, Thomas Nuttall, Jan Townsend   +2 more
openalex   +2 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Factors influencing the choice of non-biologic versus biologic immunosuppressive therapy in systemic lupus erythematosus. [PDF]

Sci Rep
Bortoluzzi A, Marangoni A, Silvagni E, Rozza D, Bartoloni E, Blagojevic J, Pallavicini FB, Bozzolo E, Canti V, Cavagna L, Cavazzana I, Coladonato L, Conigliaro P, Crisafulli F, Ditto MC, Emmi G, Ferrigno S, Franceschini F, Frassi M, Garaffoni C, Gerosa M, Govoni M, Guiducci S, Iaccarino L, Manfredi A, Mancuso S, Mosca M, Naclerio C, Orefice V, Parisi S, Pazzola G, Pettiti G, Prevete I, Ramirez GA, Scirocco C, Spinelli FR, Zen M, Carrara G, Scirè CA, Conti F, Doria A, Sebastiani GD.   +41 more
europepmc   +1 more source

LIV.—On a Collection of Bats from Paraguay [PDF]

, 1901
Oldfield Thomas
openalex   +1 more source