Results 251 to 260 of about 23,716,382 (381)
CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceWorking across religions, cultures, settings, and development: Protocol for wave 2 data collection with children and parents by the developing belief network
Allison J. Williams, Kara Weisman, Tamer G. Amin, Maliki E. Ghossainy, Ghadir Soueidan, Jenny Nissel, Praveen Kenderla, Mervat N. Abdelhak, Florencia K. Anggoro, Samantha Bangayan, Emily Burdett, Emily Chau, Eva E. Chen, Jallene Jia En Chua, Lezanie Coetzee, John D. Coley, Audun Dahl, Jocelyn Dautel, Elizabeth L. Davis, Helen Davis, Adine DeLeon, Gil Diesendruck, Denise Evans, Aidan Feeney, Frankie T. K. Fong, Xuqing Foo, A GARCIA, Isabela Gonzalez-Rubio, Elena Guerrero Galaz, Michael Gurven, Ying Hu, Keila Huachorunto, Komang Indrawati, Benjamin D. Jee, Michael Kahwa, Unity Kahwa, Ringking Korah, Hannah J. Kramer, Tamar Kushnir, Natassa Kyriakopoulou, Shitshembiso Lebepe, Hea Jung Lee, Kirsten A Lesage, Patricia Leshabana, Dandan Li, Pearl Han Li, Jessica Tacza Llacua, Vongani Maluleke, Ashley B. Marin, Julia Marshall, Nthabiseng Masebe, Katherine McAuliffe, Abby McLaughlin, Anthea McMullan, Caitlin McShane, Cuiting Min, Mike Mutegeki, Olive Namara, Shaun Nichols, Ageliki Nicolopoulou, Mark Nielsen, Emily Otali, Katerina Parise, Xiomara Alicia Paucar, Ayse Payir, Sakina Poonawalla, Bolivar Reyes‐Jaquez, Sophie Riddick, Peter C. Rockers, J. Ruíz, Rifah Sanjidah, Laura Shneidman, Irini Skopeliti, Mahesh Srinivasan, Jessa Stegall, J. M. Stephens, Megan G. Stutesman, Jiayue Sun, Amanda R. Tarullo, Laura K. Taylor, Itangishatse Theogen, Desiree Toong, Esra Nur Turan-Küçük, Patrick Tusiime, Estefany Pizarro Ventura, Jingyi Xu, Ni-Na Ye, Yue Yu, Meltem Yucel, Wei Zhang, Xin Zhao, Kathleen H. Corriveau, Rebekah A. Richert, on behalf of the Developing Belief Network +93 moreopenalex +2 more sourcesReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceIntein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar +9 morewiley +1 more sourceImproving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann +15 morewiley +1 more source