From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions. [PDF]
Nat Commun, 2020 Littlejohns TJ +23 more
europepmc +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Optimization of a Capacitated Vehicle Routing Problem for Sustainable Municipal Solid Waste Collection Management Using the PSO-TS Algorithm. [PDF]
Int J Environ Res Public Health, 2020 Qiao Q, Tao F, Wu H, Yu X, Zhang M.
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Establishing a workflow for assessing open monograph business models: a case study from Oxford
Insights: The UKSG JournalOpen access (OA) monograph publishing is becoming increasingly important as new funder mandates – including UKRI’s long-form OA policy – bring books and chapters into scope for compliance.
David Watson
doaj +1 more source
Novel Approach to Support Rapid Data Collection, Management, and Visualization During the COVID-19 Outbreak Response in the World Health Organization African Region: Development of a Data Summarization and Visualization Tool. [PDF]
JMIR Public Health Surveill, 2020 Ahmed K +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Revista Interamericana de Bibliotecología, 2008 Se presentan los resultados de la primera fase de investigación sobre desarrollo de colecciones que serealiza en la Biblioteca de la Universidad EARTH (Costa Rica), cuya hipótesis principal consiste endemostrar que la interacción de los procesos de ...
Ana Pérez López +4 more
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