Results 121 to 130 of about 4,158,501 (303)
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
The many meanings of collective action: lessons on enhancing gender inclusion and equity in watershed management [PDF]
"Collective action in agriculture and natural resource management is all too often perceived of in terms of the mere number of participants, with little consideration given to who participates, why, and the outcomes of inequitable participation.
Tanui, Joseph +4 more
core
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Refining relational climate conversations to promote collective action
npj Climate ActionMany US residents are worried about the climate crisis, but few are involved in collective climate action. Relational climate conversations are a commonly recommended yet understudied means of encouraging action.
Julia C. Fine
doaj +1 more source
Italian Labour Law e-JournalCollective action constitutes the most effective and progressive power of workers to promote their economic and social interests. The collective action lies at the heart of the collective bargaining systems, illustrated by a common saying, “The right to ...
Merve Kutlu Mutluer
doaj +1 more source
Everyday forms of collective action in Bangladesh: Learning from Fifteen Cases [PDF]
"This paper examines fifteen cases of collective action in six villages in rural Bangladesh. Collective action was defined broadly and identified from significant episodes in previous life-history research in the same villages.
Davis, Peter
core
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Inactive and Quiescent? Immigrant Collective Action in Comparative Perspective, 1960 to 1995
SociusSocial movement mobilization by and on behalf of immigrants occurs frequently today, but sociologists have been slow to include immigrant collective action in the canon of social movement or immigration scholarship.
Kim Voss +2 more
doaj +1 more source