Results 31 to 40 of about 143,728 (254)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Supporting the Upscaling of Citizen Science to Address Global Challenges

Citizen Science: Theory and Practice
In May 2024, a workshop was held as part of the European Citizen Science Association (ECSA) 2024 conference in Vienna to explore the creation of transnational communities to upscale citizen science, to address global issues as outlined by the European ...
James Christopher Sprinks, Liz Dowthwaite, Luigi Ceccaroni, Tim Kiessling, Dilek Fraisl, Giovanni Maccani, Ana Solange Leal, Agueda Gras-Velazquez, Arianna Liconti, Katarzyna Pydzinska Azevedo, Kaushiki Das, Stephen Parkinson, Mariana Malta   +12 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Trends in hepatitis C virus seroprevalence and associated risk factors among msm in Pakistan: insights from a community-based study

Scientific Reports
Pakistan bears a substantial burden of hepatitis C virus (HCV) infection, with the second-highest prevalence globally. This community-based cross-sectional study, conducted from January to December 2022 in Punjab, Pakistan, investigates the ...
Raza Tirmizi, Rimsha Munir, Nousheen Zaidi   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Evolution of Collective Action. [PDF]

, 2005
A public good is produced if and only if a team of m or more volunteers contribute to it. An equilibrium-selection problem leads to the questions: will the collective action succeed? If so, who will participate in the team? The paper studies the evolution of collective action: as part of a strategy-revision process, updating players choose quantal ...
David P. Myatt, Chris Wallace
openaire   +2 more sources

Hope and Anger as Mediators Between Collective Action Frames and Participation in Collective Mobilization: The Case of 15-M

Journal of Social and Political Psychology, 2017
The study set out to integrate collective action models and emphasize the role of emotions. Whereas the importance of anger is indisputable, relatively little attention has been paid to the role of positive emotions, such as hope, in collective action ...
Anna Wlodarczyk, Nekane Basabe, Darío Páez, Larraitz Zumeta   +3 more
doaj   +1 more source

Exploring social movement concepts and actions in a knowledge uptake and sustainability context: A concept analysis

International Journal of Nursing Sciences, 2022
Objectives: To share a concept analysis of social movement aimed at advancing its application to evidence uptake and sustainability in health-care. Methods: We applied Walker and Avant method to clarify the concept of social movement in the context of ...
Doris Grinspun, Katherine Wallace, Shelly-Anne Li, Susan McNeill, Janet Elaine Squires, Jesús Bujalance, Maryanne D’Arpino, Gina De Souza, Nataly Farshait, John Gabbay, Ian D. Graham, Alison Hutchinson, Kim Kinder, Celia Laur, Tina Mah, Julia E. Moore, Jennifer Plant, Jodi Ploquin, P. Jim A. Ruiter, Daphney St-Germain, Margie Sills-Maerov, May Tao, Marita Titler, Junqiang Zhao   +23 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Psychological Determinants of Collective Action for Climate Justice: Insights From Semi-Structured Interviews and Content Analysis

Frontiers in Psychology, 2021
Student initiatives for climate justice are driving forces in the climate change debate, but the psychological determinants of students’ engagement for climate justice have hardly been investigated so far.
Hannah Bührle, Joachim Kimmerle, Joachim Kimmerle   +2 more
doaj   +1 more source