Results 81 to 90 of about 143,728 (254)

Collective Action Against Research-Related Employment Precarity

Exchanges
This Critical Reflection details the individual, institutional and national impacts of employment precarity in research-related roles, summarising findings from the University of Nottingham’s Revisiting Employment Contracts: Helping Under-represented ...
Ash Collins
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Humor and social norms on social media: When bible verses or memes mobilize Christians for humanitarian collective actionOpen Science Framework

Acta Psychologica
Group members' decisions on whether or not to become actively involved in collective action are often guided by social norms regarding both action and inaction.
Hedy Greijdanus, Willem van de Wetering, Casper Roos   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Collective Action Theory: the Political Dimension

RUDN Journal of Political Science, 2011
The article is devoted to the analysis of the modern collective action theory as one of the main analytic structures dedicated to the civil society functioning.
D B Kazarinova
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Intergroup contact, outgroup knowledge and advantaged group collective action: can who you know and what you know promote social change?

Frontiers in Social Psychology
Some groups in society unjustly hold greater social, economic, and political power over others, placing some groups in more advantaged and others in more disadvantaged positions.
Caitlin Ferry, Caitlin Ferry, Cara MacInnis, Cara MacInnis, Elena Buliga   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Cultural logics of honor, face, and dignity as moderators of the relationship between group process and pro-migrant collective action intentions

Current Research in Ecological and Social Psychology
Although group identification, efficacy, and injustice appraisals are well-established predictors of collective action support, contextual factors are rarely examined.
Tomasz Besta, Emma Thomas, Goksu Celikkol, Michał Olech, Paweł Jurek, Martijn van Zomeren, Maura Pozzi, Carlo Pistoni, Marek Palace, Gulcin Akbas, Julia C. Becker, Maja Becker, Tymofii Brik, Maria Chayinska, Makiko Deguchi, Sandesh Dhakal, Kaltrina Kelmendi, Anna Kende, Natasza Kosakowska-Berezecka, Soledad de Lemus, Paul Le Dornat, Angela K.-y. Leung, Sarah E. Martiny, Rie Mizuki, Danny Osborne, Raja Intan Arifah binti Raja Reza Shah, Pravash Kumar Raut, Saba Safdar, Katherine Stroebe, Dijana Sulejmanović, Eugene Y.J. Tee, Gonneke Ton, Özden Melis Uluğ, Ana Urbiola, Anna Wlodarczyk   +34 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source