Results 51 to 60 of about 47,066 (247)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Adaptive collective foraging in groups with conflicting nutritional needs [PDF]
Royal Society Open Science, 2016 Collective foraging, based on positive feedback and quorum responses, is believed to improve the foraging efficiency of animals. Nutritional models suggest that social information transfer increases the ability of foragers with closely aligned ...
Alistair M. Senior +5 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
International Journal of Interactive Multimedia and Artificial Intelligence, 2017 In this paper, we propose a novel approach utilizing a professional Social network (Pro Social Network) and a new coordination protocol (CordiNet). Our motivation behind this article is to convince Small and Medium Enterprises managers that current ...
Noria Taghezout, Seddik Reguieg
doaj +1 more source
PLoS ONE, 2020 Understanding social organization is fundamental for the analysis of animal societies. In this study, animal single-file movement data-serialized order movements generated by simple bottom-up rules of collective movements-are informative and effective ...
Hiroki Koda, Zin Arai, Ikki Matsuda
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Agent Based Simulation of Group Emotions Evolution and Strategy Intervention in Extreme Events
Discrete Dynamics in Nature and Society, 2014 Agent based simulation method has become a prominent approach in computational modeling and analysis of public emergency management in social science research.
Bo Li +3 more
doaj +1 more source
Using synchronous Boolean networks to model several phenomena of collective behavior.
PLoS ONE, 2014 In this paper, we propose an approach for modeling and analysis of a number of phenomena of collective behavior. By collectives we mean multi-agent systems that transition from one state to another at discrete moments of time. The behavior of a member of
Stepan Kochemazov, Alexander Semenov
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Social Collective as a Modular Group Modeling Tool
IEEE AccessThis paper presents a comprehensive description of the social collective, an approach to group modeling for computational collective intelligence purposes. The social collective is independent of the structure of connections between members of the group,
Marcin Maleszka
doaj +1 more source