Results 91 to 100 of about 3,398,971 (333)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
FORMATION OF FACTORY LEGISLATION IN THE FIELD OF COLLECTIVE LABOR DISPUTES RESOLUTION
Гуманитарные и юридические исследования, 2021 The historical aspect of the study of the problems of settlement of collective labor disputes in Russia deserves closer attention, including through the prism of modern problems of legal regulation of relations in the field of labor.
T. Vysheslavova
doaj
International Journal of the Commons, 2007 While the organizational dynamics of collective management systems have received much attention, relatively little work has focused on how households adapt their economic strategies in response to collective management regulations that impose constraints
David G. McGrath +2 more
doaj +1 more source
Collective wage agreements and the adjustment of workers and hours in German service firms [PDF]
There is a growing concern about collective wage agreement and employment dynamics in Germany. In this paper, evidence is provided on the way collective wage agreements affect the adjustment of working hours, employment and other production factors when ...
Kaiser, Ulrich, Pfeiffer, Friedhelm
core
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Non-Ideal Theory in Climate Agreements
Ethic@: an International Journal for Moral Philosophy, 2018 My research explores climate justice and non-ideal theory. Using Laura Valentini’s conception of non-ideal theory, this is applied to the distribution of climate mitigation obligations, with a particular focus on the common but differentiated ...
Ushana Jayasuriya
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Thēmis, 2013 Quebec’s Labor regime, due to its particular situation, is influenced by Common Law, aswell as by Civil Law, of French origin. Both systems have consecrated the fundamental right to collective negotiation, recognizedto all workers, by limiting State ...
Francisco Fernando Villanueva González
doaj
Humanités NumériquesThis data paper outlines the various stages of the construction of the CAGE (Collective Agreements for Gender Equality) database. The database captures, for a representative sample of French companies, a comprehensive array of information on the actors ...
Anne-Sophie Bruno +2 more
doaj +1 more source