Results 41 to 50 of about 22,458 (259)

Federated proximal policy optimization with action masking: Application in collective heating systems

Energy and AI
This paper introduces a novel privacy-aware Federated Proximal Policy Optimization (FPPO) method combined with action masking. As a Federated Reinforcement Learning (FRL) approach, the proposed method is used for optimizing the reloading of Domestic Hot ...
Sara Ghane, Stef Jacobs, Furkan Elmaz, Thomas Huybrechts, Ivan Verhaert, Siegfried Mercelis   +5 more
doaj   +1 more source

Ethics of Nuclear Energy in Times of Climate Change: Escaping the Collective Action Problem

Philosophy & Technology, 2022
AbstractIn recent years, there has been an intense public debate about whether and, if so, to what extent investments in nuclear energy should be part of strategies to mitigate climate change. Here, we address this question from an ethical perspective, evaluating different strategies of energy system development in terms of three ethical criteria ...
Simon Friederich, Maarten Boudry
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Path to sustainability: Analyzing usage intention of energy-efficient appliances

Energy Nexus
In the face of global climate challenges, individual actions are crucial for achieving sustainability goals, since collective efforts to adopt energy-saving practices can lead to significant reductions in energy consumption and greenhouse gas emissions ...
Anandhi Elangovan, Manivannan Babu
doaj   +1 more source

G20 Presidency of Indonesia: Collective and Inclusive Agendas for World Development

International Journal of Technology, 2022
The Group of Twenty (G20), comprised of 19 countries and the European Union, is an intergovernmental forum for addressing issues on global economic, financial stability, climate change mitigation, and sustainable development.
Mohammed Ali Berawi
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

University-Based Smart Cities: from collective intelligence to smart crowd-conscience

The Journal of Quality in Education, 2017
Quality of life, economic, knowledge and human capitals ‘development are the main challenges of the new wave of smart cities. Hybrid strategies of cost leadership and innovation need to be aligned mostly by highly deliberate university creative ...
Mohamed Makkaoui, Fadwa Lachhab, Mohamed Bakhouya   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The land belong to us? The environmental capital of polish residents based on the example of Masovia

Economics and Environment
Research explores the concept of environmental capital among the residents of the Masovia region, analysing their attitudes and behaviours towards the environment.
Oskar Szczygieł, Dominika Zwęglińska-Gałecka , Sławomir Kalinowski   +2 more
doaj   +1 more source