Results 51 to 60 of about 7,918,890 (281)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Federated proximal policy optimization with action masking: Application in collective heating systems

Energy and AI
This paper introduces a novel privacy-aware Federated Proximal Policy Optimization (FPPO) method combined with action masking. As a Federated Reinforcement Learning (FRL) approach, the proposed method is used for optimizing the reloading of Domestic Hot ...
Sara Ghane, Stef Jacobs, Furkan Elmaz, Thomas Huybrechts, Ivan Verhaert, Siegfried Mercelis   +5 more
doaj   +1 more source

Civil and Procedural Instruments of the Consumer Protection on the Retail Electricity Market—Original Polish Model

Energies, 2022
In the article, the authors present the specificity of the Polish retail electricity market, shaped to a considerable extent by the provisions of European Union law. The main feature of this market is granting special legal protection to individual final
Waldemar Tarczyński, Kinga Flaga-Gieruszyńska   +1 more
doaj   +1 more source

GCoM datasets: a collection of climate and energy action plans with mitigation, adaptation and energy access commitments

Scientific Data
This paper presents a collection of datasets holding information on the energy and climate action plans of 6,850 municipalities, taking part in the transnational initiative of the Global Covenant of Mayors (GCoM). This collection includes commitments for reducing net GHG emissions by at least 20% by 2020, 55% by 2030 and becoming climate neutral by ...
Camilo Franco, Giulia Melica, Aldo Treville, Marta Giulia Baldi, Valentina Palermo, Paolo Bertoldi, Enrico Pisoni, Fabio Monforti-Ferrario, Monica Crippa   +8 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Path to sustainability: Analyzing usage intention of energy-efficient appliances

Energy Nexus
In the face of global climate challenges, individual actions are crucial for achieving sustainability goals, since collective efforts to adopt energy-saving practices can lead to significant reductions in energy consumption and greenhouse gas emissions ...
Anandhi Elangovan, Manivannan Babu
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

University-Based Smart Cities: from collective intelligence to smart crowd-conscience

The Journal of Quality in Education, 2017
Quality of life, economic, knowledge and human capitals ‘development are the main challenges of the new wave of smart cities. Hybrid strategies of cost leadership and innovation need to be aligned mostly by highly deliberate university creative ...
Mohamed Makkaoui, Fadwa Lachhab, Mohamed Bakhouya   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source