Results 71 to 80 of about 23,605 (277)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Assessment of the level of influence of oil exporting countries’ organizations on the world oil market

open access: yesВестник университета
Oil is one of the significant energy resources for the majority of the world’s states, so many of them monitor and analyze the price of black gold. Currently, there are such organizations of oil exporting countries as OPEC and OPEC+, which for a long time
A. A. Laznik, T. S. Gordeeva
doaj   +1 more source

Planting the future Fostering collective engagement with the energy transition by coordinated action

open access: green
Denise T. D. de Ridder   +5 more
openalex   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Standardization and benchmark initiatives for emission reduction in the petroleum industry [PDF]

open access: yesREM: International Engineering Journal
The Oil and Gas (O&G) sector is facing unprecedented challenges regarding greenhouse gas (GHG) emissions, urging rapid decarbonization actions in line with global imperatives.
Gustavo Castro Ribeiro   +4 more
doaj   +1 more source

Social Laser Model for the Bandwagon Effect: Generation of Coherent Information Waves

open access: yesEntropy, 2020
During recent years our society has often been exposed to coherent information waves of high amplitudes. These are waves of huge social energy. Often they are of destructive character, a kind of information tsunami.
Andrei Khrennikov
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Developing criteria for effective building-sector commitments in nationally determined contributions

open access: yesBuildings & Cities
The number of countries mentioning building sector climate actions in their nationally determined contributions (NDCs) has risen from 131 in 2020 to 168 in 2023. However, the wide variety of ways in which these actions are included and described makes it
Peter Graham   +2 more
doaj   +1 more source

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