Results 41 to 50 of about 4,131,535 (260)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Review of Pedestrian Flow Characteristics and Level of Service over Different Pedestrian Facilities [PDF]

, 2018
Present paper reviewed the past studies on pedestrian flow characteristics (such as speed, flow, density, space, free-flow speed and jam density) and development of Pedestrian Level of Service (PLOS) for various pedestrian facilities (i.e., sidewalk ...
Maurya, Akhilesh Kumar, Banerjee, Arunabha, Lämmel, Gregor   +2 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Characteristics of Stop and Go Wave in One Dimensional Interrupted Pedestrian Flow Through Narrow Channel [PDF]

, 2019
Pedestrian microscopic simulation models can aid crowd management only if they can reproduce the crowd behavior correctly. To calibrate and validate the model, it is important to understand crowd movement during various activities involved in mass ...
Gayathri, H., Gulhare, Siddhartha, Verma, Ashish   +2 more
core   +1 more source

A New Individual Mobility Prediction Model Applicable to Both Ordinary Conditions and Large Crowding Events

Journal of Advanced Transportation, 2023
Accurate prediction of individual mobility is crucial for developing intelligent transportation systems. However, while previous models usually focused on predicting individual mobility under ordinary conditions, the models that are applicable to large ...
Bao Guo, Kaipeng Wang, Hu Yang, Fan Zhang, Pu Wang   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Pedestrian flow characteristics through bends: Effects of angle and desired speed [PDF]

, 2020
This study quantitatively described how the desired speed, which may reflect the emergency level, and the angle of bend affect the pedestrian flow by comparing fundamental diagrams derived from trajectory data collected through laboratory experiments ...
Dias, Charitha, Zhang, Jiahua, Asano, Miho Iryo, Sarvi, Majid, Sarvi, M, Dias, C, Asano, MI, Zhang, J   +7 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Shared flow and positive collective gatherings

Anales de Psicologia
Collective gatherings or rituals promote optimal experiences in socially acceptable circumstances. Few studies have empirically examined the experience of flow shared by a group in collective situations.
Larraitz Zumeta, Nekane Basabe, Anna Wlodarczyk, Magdalena Bobowik, Darío Páez   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source