Results 71 to 80 of about 868,814 (291)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Collective flow or random walk?
Physics Letters B, 1997 Abstract Using recently measured transverse momentum spectra from 158 A GeV/ c Pb+Pb and 200 A GeV/ c S+S collisions at the CERN SPS, we address the question whether the transverse motion of hadrons produced in ultra-relativistic heavy-ion collisions is due to random walk initial state collisions or due to multi-scattering induced collective flow.
S Esumi, U Heinz, N Xu
openaire +1 more source
Analysis of iterative deblurring: no explicit noise
Open PhysicsIterative deblurring, notably the Richardson–Lucy algorithm with and without regularization, is analyzed in the context of nuclear and high-energy physics applications.
Mamba Sinethemba Neliswa +1 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Atlas of Chinese World Wide Web Ecosystem Shaped by the Collective Attention Flows.
PLoS ONE, 2016 The web can be regarded as an ecosystem of digital resources connected and shaped by collective successive behaviors of users. Knowing how people allocate limited attention on different resources is of great importance.
Xiaodan Lou +3 more
doaj +1 more source
Critical Point Fluctuations in Heavy-Ion Collisions within Molecular Dynamics with Expansion [PDF]
EPJ Web of ConferencesWe analyze particle number fluctuations near the critical endpoint of a first-order phase transition using molecular dynamics simulations of the Lennard-Jones fluid. Building on our previous study [V.A. Kuznietsov et al., Phys. Rev. C 105, 044903 (2022)],
Kuznietsov Volodymyr A. +3 more
doaj +1 more source
Effects of collective expansion on light cluster spectra in relativistic heavy ion collisions
, 1997 We discuss the interplay between collective flow and density profiles, describing light cluster production in heavy ion collisions at very high energies. Calculations are performed within the coalescence model.
Bondorf, J. P. +2 more
core +2 more sources
A continuous-flow, microfluidic fraction collection device [PDF]
Journal of Chromatography A, 2010 A microfluidic device is presented that performs electrophoretic separation coupled with fraction collection. Effluent from the 3.5 cm separation channel was focused via two sheath flow channels into one of seven collection channels. By holding the collection channels at ground potential and varying the voltage ratio at the two sheath flow channels ...
Christopher A, Baker, Michael G, Roper
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source