Results 101 to 110 of about 2,629,932 (295)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Navigating sectarianism: the Egyptian Muslim Brotherhood in the international relations of the Middle East

open access: yesPolitics and Religion
While collective identity scholarship has generated insights into how social movements construct and mobilize identities to distinguish themsleves from others, it has paid comparatively less attention to why some groups reject divisive identities and ...
May Darwich, Lujain Al-Meligy
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Translating Research to Practice on Individual and Collective Mathematics and Science Identity Formation: Pedagogical Recommendations for Teachers

open access: yesJournal of Interdisciplinary Teacher Leadership, 2019
Recruiting students to science and mathematics fields continues to be a nationwide issue, resulting in a dearth of individuals to fill present and future science and math careers.
Mona Tauber, Rebecca Hite
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

IDENTITY OF THE MODERN INDIVIDUAL IN THE CONTEXT OF SOCIAL-PHILOSOPHICAL ANALYSIS

open access: yesЕпістемологічні дослідження у філософії, соціальних і політичних науках
The article examines the problem of individual identity formation in modern conditions of neoliberalism. It is noted that the research of subjectivity, «I» (self), which is the source and condition for the formation of individual identity, actualizes ...
Вадим Іванович ПАЛАГУТА
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

EU Enlargement, Identity and the Analysis of European Foreign Policy: Identity Formation through Policy Practice [PDF]

open access: yes
The eastern enlargement of the EU provides an excellent vantage point to examine the interplay of EU identity and European foreign policy. Yet most analysis of eastern enlargement either focus on enlargement as a case of EU foreign policy or on ...
Ulrich Sedelmeier
core  

Home - About - Disclaimer - Privacy