Results 71 to 80 of about 71,825 (235)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
How Does an “Envisioned” European Identity Correspond to a “Realized” European Identity?
Politikon, 2016 As European integration progresses, scholars have become increasingly interested in the definition and development of a collective European identity. Based upon analysis of European Union (EU) policies and viewed through the lenses of constructivism and
Kelly Soderstrom
doaj +1 more source
Exploring collective identity of a group of teaching-oriented academics amid research discourse: a Chinese case. [PDF]
High Educ (Dordr), 2021 Zeng W, Fickel L.
europepmc +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Collective Memory and Cultural Identity Review
Scientific Journal of King Faisal University: Humanities and Management SciencesCollective memory is vital for understanding a society's history and cultural identity, serving as a bridge between the past and the present. The concept of cultural identity is not fixed but evolves over time, shaped by the interactions of individuals ...
Anas A. Al Humam
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
IDENTITY OF THE MODERN INDIVIDUAL IN THE CONTEXT OF SOCIAL-PHILOSOPHICAL ANALYSIS
Епістемологічні дослідження у філософії, соціальних і політичних наукахThe article examines the problem of individual identity formation in modern conditions of neoliberalism. It is noted that the research of subjectivity, «I» (self), which is the source and condition for the formation of individual identity, actualizes ...
Вадим Іванович ПАЛАГУТА
doaj +1 more source