Results 21 to 30 of about 50,617 (264)

OPINIONS ABOUT MILITARY LOGISTICS IN A TURBULENT MEDIUM SECURITY [PDF]

Annals: Series on Military Sciences, 2013
In the natural world, turbulence involves violent demonstrations, random appearances, unpredictability. Scientists have developed chaos theory to explain some possible variants of development of events that have a given initial state and a number of ...
Mircea UDRESCU, Eugen SITEANU
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

On the Ruin Problem of Collective Risk Theory

The Annals of Mathematical Statistics, 1961
0. Summary. The theory of collective risk deals with an insurance business, for which, during a time interval (0, t) (1) the total claim X(t) has a compound Poisson distribution, and (2) the gross risk premium received is Xt. The risk reserve Z(t) = u + Xt - X(t), with the initial value Z(O) = u, is a temporally homogeneous Markov process.
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Challenge of Invisible Enemies and Risk Mitigation for Parents in Educating Children in the Modern Era

Mu'adalah
This study explores the hidden challenges faced by parents in educating children in the modern era, referred to as “invisible enemies”, focusing on digital technology, individualism, academic pressure, peer influence and consumerist culture.
Arif Sugitanata, Sarah Aqila, Siti Aminah, Muhammad Hasyied Abdurrasyied   +3 more
doaj   +1 more source

Cultivating Doxastic Responsibility

Humana.Mente: Journal of Philosophical Studies, 2021
This paper addresses some of the contours of an ethics of knowledge in the context of ameliorative epistemology, where this term describes epistemological projects aimed at redressing epistemic injustices, improving collective epistemic practices, and ...
Guy Axtell
doaj  

An Item Response Theory Model of Inter-Regional Collaboration for Transportation Planning in the United States

Land, 2021
Regional governments and regional intergovernmental organizations play an increasingly important role in land use and transportation planning in many countries.
Soyoung Kim, Woo-Je Kim, Richard Clark Feiock   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source