Results 31 to 40 of about 50,617 (264)

Cooperative climate action under background risk

Scientific Reports
Addressing climate change requires collective action, yet individuals face a collective-risk social dilemma: we must invest in mitigation efforts at a personal cost, with no guarantee that others will contribute, while the benefits are shared globally ...
Hao Luo, Hanna de Boer, Oliver Musshoff, Daniel Hermann   +3 more
doaj   +1 more source

On the computation of upper approximations to ultimate ruin probabilities in case of DFR claimsize distributions

Statistica, 2007
In the present note we consider the classical continuous time model of the collective theory of risk under the assumption that the claimsize distribution is DFR (decreasing failure rate) so that, according to well known queueing results, the ultimate ...
Luca Barzanti, Corrado Corradi
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Strategic risk dominance in collective systems design

Design Science, 2019
Engineered system architectures leveraging collaboration among multiple actors across organizational boundaries are envisioned to be more flexible, robust, or efficient than independent alternatives but also carry significant downside risks from new ...
Paul T. Grogan, Ambrosio Valencia-Romero
doaj   +1 more source

Italian Community Psychology in the COVID-19 Pandemic: Shared Feelings and Thoughts in the Storytelling of University Students

Frontiers in Psychology, 2021
This study investigated how young Italian people experienced the period of peak spread of COVID-19 in their country by probing their emotions, thoughts, events, and actions related to interpersonal and community bonds.
Immacolata Di Napoli, Elisa Guidi, Caterina Arcidiacono, Ciro Esposito, Elena Marta, Cinzia Novara, Fortuna Procentese, Andrea Guazzini, Barbara Agueli, Florencia Gonzáles Leone, Patrizia Meringolo, Daniela Marzana   +11 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

IMPLEMENTATION OF FUTURES LITERACY LABS AS A REALIZATION OF THE 17TH POINT OF SDG IN DISASTER RISK REDUCTION

Journal of Social Political Sciences
This research is motivated by the urgency to find new way of looking at Disaster Risk Reduction (DRR) in the TUNA (Turbulent, Uncertain, Novel, Ambiguous) era after the COVID-19 pandemic.
Duta Aksara S. Oesman
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

A new electoral bottom-up model of institutional governance

Scientific Reports
The sustainable governance of Global Risky Commons (GRC)—global commons in the presence of a sizable risk of overall failure—is ubiquitous and requires a global solution. A prominent example is the mitigation of the adverse effects of global warming.
Carlos M. Garrido, Francisco C. Santos, Elias Fernández Domingos, Ana M. Nunes, Jorge M. Pacheco   +4 more
doaj   +1 more source