Results 31 to 40 of about 1,595,796 (291)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Inelastic electron and light scattering from the elementary electronic excitations in quantum wells: Zero magnetic field

AIP Advances, 2012
The most fundamental approach to an understanding of electronic, optical, and transport phenomena which the condensed matter physics (of conventional as well as nonconventional systems) offers is generally founded on two experiments: the inelastic ...
Manvir S. Kushwaha
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Non-local optical response of nanostructured surfaces from scattering theory

Journal of Physics Communications
Nanostructured materials are commonly described by local effective permittivities inferred from far-field propagation. However, near-field interactions and large parallel wave vectors probe spatial dispersion and limit the validity of purely local ...
Johannes Fiedler
doaj   +1 more source

Collective stimulated Brillouin scatter

, 2011
We develop a statistical theory of stimulated Brillouin backscatter (BSBS) of a spatially and temporally partially incoherent laser beam for laser fusion relevant plasma. We find a new collective regime of BSBS which has a much larger threshold than the classical threshold of a coherent beam in long-scale-length laser fusion plasma.
Korotkevich, Alexander O., Lushnikov, Pavel M., Rose, Harvey A.   +2 more
openaire   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Inelastic neutron scattering applied to the investigation of collective excitations in topologically disordered matter

Condensed Matter Physics, 2008
Inelastic neutron scattering techniques are introduced here as one of the most important experimental techniques in the investigation of collective excitations in fluids (liquids and compressed gases) and amorphous solids.
J.-B.Suck
doaj   +1 more source

A structure-informed approach to analyzing scattering information [PDF]

EPJ Web of Conferences
Analyses of low-energy elastic scattering cross-section data usually involve fitting the data with phenomenological models, such as R-matrix theory. Alternatives that obtain scattering observables from the underlying nuclear physics of colliding nuclei ...
Fraser Paul, Bhattacharyya Deeparna, Amos Ken, Canton Luciano, Karataglidis Steven, Moss Robert, Murulane Khuliso   +6 more
doaj   +1 more source

Experimental mapping of short-wavelength phonons in proteins

The Innovation, 2022
Phonons are quasi-particles, observed as lattice vibrations in periodic materials, that often dampen in the presence of structural perturbations. Nevertheless, phonon-like collective excitations exist in highly complex systems, such as proteins, although
Utsab R. Shrestha, Eugene Mamontov, Hugh M. O'Neill, Qiu Zhang, Alexander I. Kolesnikov, Xiangqiang Chu   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source