Results 101 to 110 of about 198,946 (309)

PREVENTION AND TREATMENT OF MUCOSITIS AT AN ONCOLOGY OUTPATIENT CLINIC: A COLLECTIVE CONSTRUCTION

Texto & Contexto Enfermagem, 2016
El objetivo fue elaborar un protocolo asistencial de enfermería para prevención y tratamiento de la mucositis inducida por quimioterapia en un ambulatorio de un Centro de Alta Complejidad en Oncología. Investigación cualitativa del tipo
Lívia Dantas Lopes, Andrea Bezerra Rodrigues, Débora Rabelo Magalhães Brasil, Maysa Mayran Chaves Moreira, Juliana Gimenez Amaral, Patrícia Peres de Oliveira   +5 more
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Evaluation of treatment responsivity in a psychopathic prison treatment sample

, 2010
Although punishment still dominates the criminal justice system, the progression of research on offending and imprisonment has led to a general consensus that rehabilitation programmes are the appropriate method to effectively reduce both recidivism and ...
Champion, Michelle Elizabeth
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Collective Action Clauses in International Sovereign Bond Contracts – Whence the Opposition?

In the debate on strengthening the international financial architecture, which peaked in 2002 after a series of emerging market sovereign debt crises, the universal adoption of collective action clauses (CACs) was the most promising reform proposal ...
Soenke Haeseler
core  

Semianalytical treatment of collective vibrational strong coupling in infrared phononic and plasmonic nanoantennas

The interaction between nanoantenna electromagnetic modes and molecular vibrations enables key nanophotonic applications such as ultrasensitive vibrational spectroscopy and molecular sensing.
Aizpurua, Javier, Esteban, Ruben, Sepúlveda, Jonathan, Montaño-Priede, José Luis   +3 more
core   +1 more source

Rising with One’s Community: Socialist Theory and Bildungsroman in Lewis Jones

Cultura, Lenguaje y Representación, 2009
  This article analyses theoretical and ideological tensions in the fictional work of Welsh miner-author Lewis Jones. It surveys its treatment of standard categories in the Marxist-Leninist canon and pays particular attention to the shaping role of ...
Roberto Ramón del Valle Alcalá
doaj