Results 121 to 130 of about 198,946 (309)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Multi-Family Households in a Labour Supply Model: A Calibration Method with Application to Poland [PDF]
The collective model of labour supply opened the household “black box” and allowed for individual treatment of partners in couples. However, the literature on labour supply has so far largely ignored a broader issue with special relevance to transition ...
Myck, Michal, Haan, Peter
core
Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2019 The study presents the results of the analysis of investment expenditure incurred for the development of selected devices and technical infrastructure facilities serving environmental protection in the Lower Silesian village in 2007-2016.
Joanna Szymańska
doaj
Kernel Treatment Effects with Adaptively Collected Data
CoRRAdaptive experiments improve efficiency by adjusting treatment assignments based on past outcomes, but this adaptivity breaks the i.i.d.\ assumptions that underpin classical asymptotics. At the same time, many questions of interest are distributional, extending beyond average effects.
Houssam Zenati +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 1992 In Japan there are about 1200 collective night-soil treatment plants which treat about 42,700,000 population equivalent of night soil and 30,000,000 population equivalent of on-site treatment tank sludge.
M. Tanaka +3 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Isospin-symmetry violation. Collective treatment of the I.A.S
, 2004 We study the effects of isospin symmetry violation in the description of the isobaric analogue state (I.A.S.). The sources of such violation are either spurious (like isospin violations induced by the choice of the independent-particle basis), or have a ...
D R Bes, O Civitarese
core
Machine learning is transforming the investigation of complex biological processes. In enzymatic catalysis, one significant challenge is identifying the reactive conformations of the enzyme:substrate complex where the substrate assumes a precise ...
Maria J., Ramos +4 more
core +1 more source