Results 61 to 70 of about 74,897 (302)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Systematic Reviews, 2019 Background Polycystic ovary syndrome (PCOS) is the most common endocrinopathy, affecting 4–12% of reproductive-aged women. Women with PCOS often exhibit many metabolic abnormalities that are associated with an increased cardiovascular disease (CVD) risk,
Amie Woodward +6 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
An Analysis of Behaviour Change Techniques Used in a Sample of Gestational Weight Management Trials
Journal of Pregnancy, 2016 Introduction. Maternal obesity and excessive gestational weight gain are associated with multiple adverse outcomes. There is a lack of clarity on the specific components of effective interventions to support pregnant women with gestational weight ...
H. Soltani +3 more
doaj +1 more source
Peterborough Collegiate Institute Commencement Exercises Friday, March 1st, 1912
, 1912 A programme of the commencement exercises for Peterborough Collegiate Institute in the year 1912. Within the programme, Estelle Cuffe is listed as an "honours normal entrace" candidate.
Peterborough Collegiate Institute
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Antitumor activity of 2 new evodiamine derivatives against small-cell lung cancer cells in vitro
Di-san junyi daxue xuebao, 2019 Objective To investigate the antitumor activity and the underlying mechanisms of 2 new derivatives of evodiamine (EVO), namely nitro evodiamine derivatives (END) and amino evodiamine derivatives (EAD), in cultured small-cell lung cancer (SCLC) cells ...
JIANG Xuejun +4 more
doaj +1 more source
Lethbridge Collegiate Institute Spotlite 1962
, 2016 The annual publication of the students of Lethbridge Collegiate Institute, Lethbridge, Alberta.(1961-62)pdfThis Book Is respectfully Dedicated To MR. D. S. A.
Lethbridge Collegiate Institute
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source