Results 81 to 90 of about 402,611 (314)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Journal of Experimental OrthopaedicsPurpose The global rise in popularity of basketball has prompted an increased emphasis on understanding the injury patterns affecting players. This study analysed injury epidemiology and return to sport outcomes in Division I male and female collegiate ...
Rishi Trikha +6 more
doaj +1 more source
The Impact and Prospect of China’s Low Interest Rates on the Economy [PDF]
SHS Web of ConferencesThis article explores the impact of China’s long-term low-interest-rate policy on its economy and its future development direction. While the low-interest-rate policy has stimulated investment and consumption, it has also led to risks such as rising ...
Fu Jiarui
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
The Issue of Compensation: Should NCAA Athletes be Compensated Above Their Scholarships [PDF]
, 2018 There is an issue of National Collegiate Athletic Association (NCAA) student-athletes being exploited by their respective universities and a need for change in the way the student-athletes are being compensated for their efforts.
Cook, Justen
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Canadian Journal of Bioethics, 2019 This book review considers the challenges of raising a child with a developmental disability as seen in the book What time is the 9:20 bus? by Lucinda Hage.
Aedan Garcia
doaj +1 more source
, 2019 Professional development of teachers normally ends after formal collegiate education. Agora desires to help educators continually train, to learn the skills of good teaching in classrooms by using various, non-traditional methodologies.
Burns, Sam +2 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source