Results 81 to 90 of about 74,897 (302)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A multicenter epidemiologic analysis of the injuries affecting female and male collegiate basketball players

Journal of Experimental Orthopaedics
Purpose The global rise in popularity of basketball has prompted an increased emphasis on understanding the injury patterns affecting players. This study analysed injury epidemiology and return to sport outcomes in Division I male and female collegiate ...
Rishi Trikha, Nicole J. Hung, Daniel J. Chernoff, Clayton Del Prince, Sharon L. Hame, Kristofer J. Jones, Thomas J. Kremen   +6 more
doaj   +1 more source

Lethbridge Collegiate Institute Spotlite 1953

, 2016
The annual publication of the students of Lethbridge Collegiate Institute, Lethbridge, Alberta.(1952-53)pdfThe Annual Publication of the Students' Union of the Lethbridge Collegiate Institute - 1953Page Two LETHBRIDGE COLLEGIATE INSTITUTE Dedication In ...
Lethbridge Collegiate Institute
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Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Lethbridge Collegiate Institute Spotlite 1950

, 2016
The annual publication of the students of Lethbridge Collegiate Institute, Lethbridge, Alberta.(1949-50)pdfICE CREAM Always a “Pick-up” No matter how you get it, ice cream never fails to leave refreshment, nourishment, a real “pick-up” behind it If it’s ...
Lethbridge Collegiate Institute
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PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Book Review: What time is the 9:20 bus? A Journey to a Meaningful Life, Disability and All, by Lucinda Hage (2014)

Canadian Journal of Bioethics, 2019
This book review considers the challenges of raising a child with a developmental disability as seen in the book What time is the 9:20 bus? by Lucinda Hage.
Aedan Garcia
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Lethbridge Collegiate Institute Valedicta 1933

, 2017
The annual publication of the students of Lethbridge Collegiate Institute, Lethbridge, Alberta (Volume 1932-33)pdfTHE VALEDICTA JUNE 1933 LETHBRIDGE COLLEGIATE INSTITUTE The Teco Snack Counter Ice Cream Sundaes, assorted flavors ..........................
Lethbridge Collegiate Institute
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