Results 51 to 60 of about 1,420,902 (265)

Unraveling the metastasis‐preventing effect of miR‐200c in vitro and in vivo

Molecular Oncology, EarlyView.
Advanced tumors and ineffective cancer treatments can lead to metastases in distant organs. The sole expression of microRNA 200c (miR‐200c) in breast cancer cells is shown to significantly reduce metastasis formation in xenograft mouse models. Various in vitro analyses revealed impeded migratory behavior, upon miR‐200c expression, as one prerequisite ...
Bianca Köhler, Emily Brieger, Tom Brandstätter, Elisa Hörterer, Ulrich Wilk, Jana Pöhmerer, Anna Jötten, Philipp Paulitschke, Chase P. Broedersz, Stefan Zahler, Joachim O. Rädler, Ernst Wagner, Andreas Roidl   +12 more
wiley   +1 more source

Redundant neural vision systems: competing for collision recognition roles [PDF]

, 2013
Ability to detect collisions is vital for future robots that interact with humans in complex visual environments. Lobula giant movement detectors (LGMD) and directional selective neurons (DSNs) are two types of identified neurons found in the visual ...
Rind, F. Claire, Yue, Shigang
core   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Geodynamic evolution of a wide plate boundary in the Western Mediterranean, near-field versus far-field interactions

BSGF - Earth Sciences Bulletin, 2021
The present-day tectonic setting of the Western Mediterranean region, from the Pyrénées to the Betics and from the Alps to the Atlas, results from a complex 3-D geodynamic evolution involving the interactions between the Africa, Eurasia and Iberia plates
Jolivet Laurent, Baudin Thierry, Calassou Sylvain, Chevrot Sébastien, Ford Mary, Issautier Benoit, Lasseur Eric, Masini Emmanuel, Manatschal Gianreto, Mouthereau Frédéric, Thinon Isabelle, Vidal Olivier   +11 more
doaj   +1 more source

Motion planning with sequential convex optimization and convex collision checking

Int. J. Robotics Res., 2014
We present a new optimization-based approach for robotic motion planning among obstacles. Like CHOMP (Covariant Hamiltonian Optimization for Motion Planning), our algorithm can be used to find collision-free trajectories from naïve, straight-line ...
John Schulman, Yan Duan, Jonathan Ho, Alex X. Lee, I. Awwal, H. Bradlow, Jia Pan, S. Patil, Ken Goldberg, P. Abbeel   +9 more
semanticscholar   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Energy and Centrality dependence of $dN_{\rm ch}/d\eta$ and $dE_{\rm T}/d\eta$ in Heavy-Ion Collisions from $\sqrt{s_{\rm NN}}$ =7.7 GeV to 5.02 TeV

, 2016
The centrality dependence of pseudorapidity density of charged particles and transverse energy is studied for a wide range of collision energies for heavy-ion collisions at midrapidity from 7.7 GeV to 5.02 TeV.
Behera, Nirbhay K., Mishra, Aditya Nath, Nandi, Basanta K., Pareek, Pooja, Sahoo, Pragati, Sahoo, Raghunath   +5 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Effects of acceleration on the collision of particles in the rotating black hole spacetime

, 2012
We study the collision of two geodesic particles in the accelerating and rotating black hole spacetime and probe the effects of the acceleration of black hole on the center-of-mass energy of the colliding particles and on the high-velocity collision ...
A. Williams, A.A. Grib, A.A. Grib, B. Carter, C.Q. Liu, Changqing Liu, E. Berti, I. Bengtsson, J. Podolský, J.B. Griffiths, J.B. Griffiths, J.F. Plebański, J.L. Said, Jiliang Jing, K. Lake, M. Banados, M. Banados, M. Banados, M. Kimura, M. Patil, M. Patil, M. Patil, O.B. Zaslavskii, O.B. Zaslavskii, O.B. Zaslavskii, R.P. Kerr, S.W. Hawking, S.W. Wei, S.W. Wei, Songbai Chen, T. Harada, T. Jacobson, U.A. Gillani, Weiping Yao, Y. Zhu, Y. Zhu   +35 more
core   +1 more source