Results 61 to 70 of about 1,420,902 (265)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Investigation of the Dynamic Buckling of Spherical Shell Structures Due to Subsea Collisions

Applied Sciences, 2018
This paper is the first to present the dynamic buckling behavior of spherical shell structures colliding with an obstacle block under the sea. The effect of deep water has been considered as a uniform external pressure by simplifying the effect of fluid ...
Ping Liu, Sakdirat Kaewunruen, Dao Chuan Zhao, Shui Wang Shang   +3 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Bird and bat species' global vulnerability to collision mortality at wind farms revealed through a trait-based assessment

Proceedings of the Royal Society B: Biological Sciences, 2017
Mitigation of anthropogenic climate change involves deployments of renewable energy worldwide, including wind farms, which can pose a significant collision risk to volant animals.
C. Thaxter, G. Buchanan, J. Carr, S. Butchart, T. Newbold, R. Green, J. Tobias, W. Foden, S. O'Brien, J. Pearce‐Higgins   +9 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Vortex Collisions: Crossing or Recombination?

, 2001
We investigate the collision of two vortex lines moving with viscous dynamics and driven towards each other by an applied current. Using London theory in the approach phase we observe a non-trivial vortex conformation producing anti-parallel segments ...
A. Campbell, A. Schmid, A. Schönenberger, A. Sudbo, B. D. Josephson, C. R. Hu, D. Lopez, D. Lopez, E. H. Brandt, E. P. S. Shellard, G. Blatter, G. Blatter, Gianni Blatter, H. Safar, J. Koplik, J. R. Clem, J. R. Clem, K. W. Schwarz, K. W. Schwarz, L. M. A. Bettencourt, M. C. Marchetti, M. E. Cates, M. J. W. Dodgson, M. Moore, M. Tinkham, Malek Bou-Diab, Matthew J. W. Dodgson, P. Laguna, P. Wagenleithner, R. Busch, S. P. Obukhov   +30 more
core   +1 more source

Magmatic record of India-Asia collision

Scientific Reports, 2015
New geochronological and geochemical data on magmatic activity from the India-Asia collision zone enables recognition of a distinct magmatic flare-up event that we ascribe to slab breakoff.
Di‐Cheng Zhu, Qing Wang, Zhidan Zhao, Sun‐Lin Chung, Peter A. Cawood, Y. Niu, Shengwen Liu, Fu-Yuan Wu, X. Mo   +8 more
semanticscholar   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Pre-collisional geodynamics of the Mediterranean Sea: the Mediterranean Ridge and the Tyrrhenian Sea

Annals of Geophysics, 1997
Today the Mediterranean Sea consists of a series of small-sized and almost geographically disconnected oceanic or continental crust rooted marine basins.
E. Chaumillon, J. Mascle
doaj   +1 more source

Energy-efficient collision-free medium access control for wireless sensor networks

ACM International Conference on Embedded Networked Sensor Systems, 2003
The traffic-adaptive medium access protocol (TRAMA) is introduced for energy-efficient collision-free channel access in wireless sensor networks. TRAMA reduces energy consumption by ensuring that unicast, multicast, and broadcast transmissions have no ...
V. Rajendran, K. Obraczka, J. Garcia-Luna-Aceves   +2 more
semanticscholar   +1 more source