Results 111 to 120 of about 1,691,785 (320)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Cryptanalysis of 48-step RIPEMD-160

IACR Transactions on Symmetric Cryptology, 2017
In this paper, we show how to theoretically compute the step differential probability of RIPEMD-160 under the condition that only one internal variable contains difference and the difference is a power of 2.
Gaoli Wang, Yanzhao Shen, Fukang Liu
doaj   +1 more source

Nanoconfinement‐Steered Molecular Preorganization Enables Efficient Monoethanolamine Degradation through Electronically Modulated High‐Valent Iron–Oxo Pathways

Advanced Science, EarlyView.
Precise modulation of reaction pathways remains an unresolved challenge in peroxymonosulfate‐activated advanced oxidation processes. The spatial preorganization strategy in engineered confinement architecture enables regioselective bond cleavage in monoethanolamine via synergistic proton–electron transfer, redirecting its degradation from nonselective ...
Lin Zhang, Qin Dai, Xinyue Chen, Hang Yuan, Lei Xing, Zhimo Fang, Xiuze Li, Xiangke Wang, Lihui Zhang, Junping Zhao, Qiangwei Li, Lidong Wang   +11 more
wiley   +1 more source

Quantum Random Oracle Model for Quantum Public-Key Encryption

IEEE Access, 2019
Random oracle model is a general security analysis tool for rigorous security proof and effective cryptographic protocol design. In the quantum world, the attempts of constructing a quantum random oracle (QRO) have been made, such as quantum-accessible ...
Tao Shang, Ranyiliu Chen, Qi Lei
doaj   +1 more source

An Energy Aware and Secure MAC Protocol for Tackling Denial of Sleep Attacks in Wireless Sensor Networks [PDF]

, 2019
Wireless sensor networks which form part of the core for the Internet of Things consist of resource constrained sensors that are usually powered by batteries. Therefore, careful energy awareness is essential when working with these devices.
Udoh, E., Udoh, E.
core  

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Preimage and collision attacks on reduced Ascon using algebraic strategies

Cybersecurity
Ascon, a family of algorithms that supports hashing and authenticated encryption, is the winner of the NIST Lightweight Cryptography Project. In this paper, we propose an improved preimage attack against 2-round Ascon-XOF-64 with a complexity of $$2^{33}$
Qinggan Fu, Ye Luo, Qianqian Yang, Ling Song   +3 more
doaj   +1 more source

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

Defending Against Firmware Cyber Attacks on Safety-Critical Systems [PDF]

, 2017
In the past, it was not possible to update the underlying software in many industrial control devices. Engineering teams had to ‘rip and replace’ obsolete components.
Barker, Tom, Cook, Marco, Evangelopoulou, Maria, Harkness, Rob, Johnson, Chris W., Saleem, Mohammed Hashim   +5 more
core  

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source