Results 121 to 130 of about 133,184 (295)

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

open access: yesAdvanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li   +24 more
wiley   +1 more source

Defending Against Firmware Cyber Attacks on Safety-Critical Systems [PDF]

open access: yes, 2017
In the past, it was not possible to update the underlying software in many industrial control devices. Engineering teams had to ‘rip and replace’ obsolete components.
Barker, Tom   +5 more
core  

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

open access: yesAdvanced Science, EarlyView.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino   +21 more
wiley   +1 more source

On the Power of Fault Sensitivity Analysis and Collision Side-Channel Attacks in a Combined Setting [PDF]

open access: bronze, 2011
Amir Moradi   +5 more
openalex   +1 more source

Inverse Co‐Design of Mechanical And Sensory Properties in Soft Lattice Foams for Multifunctional Wearables

open access: yesAdvanced Science, EarlyView.
An inverse co‐design framework integrates neural networks and physics‐based models to engineer soft lattice foams with independently tunable mechanical and sensory properties. By layering architected foams and optimizing electrode placement, this method enables multifunctional wearable sensors.
Qinghua Guan   +3 more
wiley   +1 more source

Revealing a Pathway for Low‐Temperature Recrystallization in Germanium

open access: yesAdvanced Science, EarlyView.
This study reports the discovery that energy transferred to electrons and atoms by highly ionizing ions results in a disorder‐order (amorphous‐crystalline) phase transformation in noncrystalline (amorphous) Ge. This discovery unlocks low‐temperature recrystallization pathways in Ge, offering a nonthermal strategy for fabricating Ge‐based devices that ...
Gihan Velişa   +8 more
wiley   +1 more source

Demo: Sequential Attacks on Kalman Filter-based Forward Collision Warning Systems

open access: bronze, 2021
Yuzhe Ma   +4 more
openalex   +1 more source

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

open access: yesAdvanced Science, EarlyView.
Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang   +8 more
wiley   +1 more source

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