Results 131 to 140 of about 133,184 (295)

Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy

open access: yesAdvanced Science, EarlyView.
Ischemic stroke is a serious disease with high rates of mortality and disability, but there is a lack of novel therapeutic targets and agents for it. Now it is shown that Ras GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) has the potential to serve as a therapeutic target for ischemic stroke.
Heyanhao Zhang   +10 more
wiley   +1 more source

SP1‐Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Laser capture microdissection‐based proteomics of pancreatic intraepithelial neoplasia (PanIN) identifies specificity protein 1 (SP1) as a key driver of tumorigenesis and progression in pancreatic cancer through glycolytic remodeling. SP1 enhances aerobic glycolysis by transcriptionally activating 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase ...
Hexing Hang   +21 more
wiley   +1 more source

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

open access: yesAdvanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou   +13 more
wiley   +1 more source

In Situ Visualization of Electron Beam‐Driven High‐Entropy Alloy Crystallization

open access: yesAdvanced Science, EarlyView.
In situ transmission electron microscopy visualizes the electron beam‐driven crystallization of amorphous multielement glycerolate film into single‐phase high‐entropy alloy (HEA) nanoparticles. The athermal process proceeds via radiolytic reduction and localized atomic rearrangement, forming compositionally uniform, cuboidal face‐centered cubic HEA ...
Azadeh Amiri, Reza Shahbazian‐Yassar
wiley   +1 more source

Rational Grain Boundary Segregation Enables Long‐Term Thermally Stable, Catalytically Active, and CO‐Tolerant Nanograined Metals

open access: yesAdvanced Science, EarlyView.
Grain boundaries endow nanocrystalline metals with unique functions but suffer thermal instability. In boron‐segregated platinum, stability depends critically on segregation level—sub‐equilibrium concentrations strengthen boundaries, whereas oversaturation induces decohesion.
Xin Geng   +3 more
wiley   +1 more source

Probing the Dynamics Process of High‐Entropy Alloy Catalysts: Fundamentals, Synthesis, and In Situ TEM Insights

open access: yesAdvanced Science, EarlyView.
Schematic illustration of the basic properties, machine learning synthesis strategy, and formation under in situ TEM of HEAs. Abstract Catalysts play a crucial role in advancing green and clean energy technologies for a sustainable future. Among the various catalysts reported, high‐entropy alloys (HEAs) stand out due to their superior stability and ...
Haider Ali, Yan Xu, Xiao Han, Yue Lin
wiley   +1 more source

Symmetry Breaking in Chemical Systems: Engineering Complexity Through Self‐Organization and Marangoni Flows

open access: yesAdvanced Science, EarlyView.
We show that solutal Marangoni flows in thin films climbing the outer surfaces of hydrophilic obstacles break circular Belousov‐Zhabotinsky waves into striking flower‐like patterns. Evaporation‐driven surface‐tension gradients, coupled with gravity, trigger the instability; above a threshold, petal number scales linearly with obstacle diameter ...
Sangram Gore   +9 more
wiley   +1 more source

Soft Micromanipulation Robot for Real‐Time Adaptive Multimodal Operation

open access: yesAdvanced Science, EarlyView.
This manuscript proposes a soft micromanipulator robot (SMR) for “full‐angle” precision biomedical operations. Bio‐inspired SMR achieves omnidirectional motion, micrometer precision, and multimodal capabilities including aspiration, transfer, rotation, assembly, injection, and cutting.
Zhuowei Li   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy