Results 191 to 200 of about 279,849 (339)

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Multimodal Locomotion: Next Generation Aerial–Terrestrial Mobile Robotics

Advanced Intelligent Systems, EarlyView., 2023
Aerial–terrestrial robots can achieve efficient energy consumption and robust environmental interaction by adding morphological features, adapting forms for locomotion transitions, and integrating multiple platforms. This next generation of mobile robots advances real‐world robotic deployment for operations with complex tasks and tackle environments ...
Jane Pauline Ramirez, Salua Hamaza
wiley   +1 more source

A Review on Additive Manufactured Engineering Materials for Enhanced Road Safety and Transportation Applications. [PDF]

Polymers (Basel)
Alparslan C, Yentimur MF, Kütük-Sert T, Bayraktar Ş.   +3 more
europepmc   +1 more source

Reinforced Granular Hydrogels Scaffolds with Tunable Physicochemical Properties for Advanced Skin Tissue Engineering

Advanced Science, EarlyView.
This work introduces a highly customizable granular hydrogel scaffold, designed from reactive microparticles through binary macromonomer microdroplet assembly, achieving a precise balance of mechanical strength and biological functionality. Abstract Engineering bioscaffolds with tailored architectures and optimized physicochemical properties remains a ...
Jing Zhang, Yijia Wang, Yue Liu, Guanfu Wu, Guilong Lu, Yue Li, Yu Shen, Caifeng Wang, Mehdi Khanmohammadi, Wojciech Święszkowski, Jing Wang, Ziyi Yu   +11 more
wiley   +1 more source

Ship-Bridge Collision Real-Time Alarming Method Based on Cointegration Theory. [PDF]

Sensors (Basel)
Zhong W, Liu D, Xie C, Zhang K, Zhan W, Cao M, Zhang Y.   +6 more
europepmc   +1 more source

Load analysis on the drone protection cage increasing collision resistance

Wojciech Skarka, Magdalena Szczepanek, Maciej Pośpiech, Aleksander Jassak, Jakub Żymełka, Michał Pokrzywa, Michał Górka, R. Niestrój   +7 more
openalex   +1 more source

Deciphering the Metabolic Impact and Clinical Relevance of N‐Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling

Advanced Science, EarlyView.
The comprehensive proteomic and N‐glycoproteomic analyses of 45 colorectal cancer tissues with matched normal adjacent tissues identified 7125 intact N‐glycopeptides from 704 glycoproteins. A glycosylation site‐protein function network revealing metabolic dysregulation is constructed and a model differentiating tumors from normal tissues is developed ...
Guobin Liu, Lu Chen, Jingxiang Zhao, Yue Jiang, Yarong Guo, Xiang Mao, Xuelian Ren, Kun Liu, Qi Mei, Qunyi Li, He Huang   +10 more
wiley   +1 more source

An advanced robotic system incorporating haptic feedback for precision cardiac ablation procedures. [PDF]

Sci Rep
Zhang L, Zuo J, Wang K, Jiang T, Gu S, Xu L, Zhang Y.   +6 more
europepmc   +1 more source

Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

Advanced Science, EarlyView.
The biosynthetic mechanism of novel natural tetramic acid S‐TeA in Alternaria alternata is elucidated. Threonine acts as a precursor for 2‐amino‐3‐methylhexanoic acid (AMHA) synthesis via eight key enzymes from the branched‐chain amino acid biosynthetic pathway in the mitochondrion, wherein three unique enzymes (IPMS, IPMDH, and ISMD) play critical ...
He Wang, Yanjing Guo, Qing Liu, Jing Zhang, Qianlong Zhang, Mingying Yang, Qizhen Chen, Sheng Qiang, Bernal E. Valverde, Shiguo Chen   +9 more
wiley   +1 more source

Simulation and experimental study on olive drop injury

Smart Agricultural Technology
Inadequate harvesting and post-harvest handling of olives can damage the fruit and seriously affect the quality of the extracted oil. In this study, vibration harvesting drop tests and finite element simulations were performed on the olive variety ...
Weike Lan, Haotian Mu, Di Xin, Shijia Pan, Yuncai Yan, Wen Gao, Zijie Niu, Dongyan Zhang, Jun Zhang, Yongjie Cui   +9 more
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