Results 111 to 120 of about 67,998 (277)

Dysplasia in sessile serrated lesions: frequency, interobserver variability and added value of immunohistochemistry

Histopathology, EarlyView.
Sessile serrated lesions with dysplasia represent a critical step in colorectal carcinogenesis. While routine histologic diagnosis is generally reliable and positive diagnostic trends are observed, subtle dysplastic changes may be overlooked. Targeted use of MLH1 immunohistochemistry provides meaningful diagnostic support in selected sessile serrated ...
Valentina Angerilli, M. Elisa Vink‐Börger, Nanette S. van Roermund, Gesina van Lijnschoten, Chantal C.H.J. Kuijpers, Nicole C.T. van Grieken, Matteo Fassan, Joep E. Ijspeert, Rachel S. van der Post, Iris D. Nagtegaal   +9 more
wiley   +1 more source

Drug‐induced hypersensitivity syndrome followed by exacerbation of Crohn's disease

Pediatric Investigation, EarlyView.
Mei Kamidani, Ryo Tanaka, Hiroshi Oue, Risa Fukuda, Rena Hashimoto, Ichiro Takeuchi, Takako Yoshioka, Naoya Tonegawa, Akira Ishiguro, Katsuhiro Arai, Kazue Yoshida   +10 more
wiley   +1 more source

The junction between the midgut and hindgut co‐localizes with the rectosigmoid junction

Journal of Anatomy, EarlyView.
At 5 weeks of development, the midgut has formed its primary loop (left). It is well established that the midgut is bounded cranially by the caudal end of the ventral mesentery and the presence of the common bile duct, but its caudal boundary remains to be established.
Hui Gao, Nutmethee Kruepunga, Greet Mommen, Susanne E. Köhler, Jill P. J. M. Hikspoors, Wouter H. Lamers   +5 more
wiley   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

Mesh Fixation to the Sacral Promontory From the Left Side of the Mesosigmoid: Two Cases of Robot‐Assisted Sacrocolpopexy for Persistent Descending Mesocolon

IJU Case Reports
Introduction Persistent descending mesocolon is a congenital fixation abnormality where the left‐sided colon deviates medially. When significantly displaced to the right, it may affect sacrocolpopexy.
Kojiro Tanabe, Yasuno Takahashi, Yuki Takahashi, Ryohei Hashimoto, Yoshiko Oyama, Yuko Hatakeyama, Hitoshi Niikura   +6 more
doaj   +1 more source

Length of the Adult Human Colon in Health and Constipation Measured Using Magnetic Resonance Imaging

Neurogastroenterology &Motility, EarlyView.
Colon length was measured in adult healthy volunteers, people with chronic constipation, and people with IBS with constipation using MRI. Colon length is significantly longer in chronic constipation. The chronically constipated colon is unable to accommodate longitudinally in response to fluid influx from a macrogol challenge.
Faiz Alqarni, Soma Kumasaka, Caroline L. Hoad, Victoria Wilkinson‐Smith, Stuart Taylor, David Atkinson, Iyad Naim, Alex Menys, S. Mark Scott, Marc A. Benninga, Hayfa Sharif, Penny A. Gowland, Moira A. Taylor, Guruprasad P. Aithal, Robin C. Spiller, Maura Corsetti, Luca Marciani   +16 more
wiley   +1 more source

Cadaveric addendum to the consensus on ultrasound‐based lymph‐node staging in gynecological cancer

Ultrasound in Obstetrics &Gynecology, EarlyView.
D. Fischerova, E. Farsi, E. Facchetti, E. Panizzolo, G. Gambino, H. Reina, F. Sousa, M. R. Kadajari, N. Tiszlavicz, G. Garganese, O. Nanka, Collaborators, E. Gatti, C. Culcasi   +13 more
wiley   +1 more source

Effect of Linaclotide on Colonic Motility Assessed With Intraluminal Colonic High‐Resolution Manometry in Healthy Subjects. An Acute, Open Label, Randomized, Crossover, Reader‐Blinded Study

Neurogastroenterology &Motility, EarlyView.
Our study showed that, in healthy controls, acute administration of linaclotide increased the total number of long‐distance propagating and the pre‐prandial pancolonic pressurizations. Further studies need to address whether the observed effects are directly or indirectly mediated by the mechanism of action of this useful medication to treat chronic ...
Christian Lambiase, Giuseppe Pagliaro, Silvia Cocca, Eveline Deloose, Ingrid Demedts, Riccardo Morganti, Jan Tack, Maura Corsetti   +7 more
wiley   +1 more source

Laws and Reasons Why

Analytic Philosophy, EarlyView.
ABSTRACT Laws play some role in explanations: at the very least, they somehow connect what is explained, or the explanandum, to what explains, or the explanans. Thus, thermodynamical laws connect the match's being struck and its lightning, so that the former causes the latter; and laws about set formation connect Socrates' existence with {Socrates}'s ...
Julio De Rizzo
wiley   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source