Results 111 to 120 of about 49,238 (225)

Synchronous Tumor of Colorectal Adenocarcinoma and Epstein‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT The third reported case of synchronous colorectal adenocarcinoma and EBV‐positive DLBCL in an 87‐year‐old patient confirms the rarity of this synchronous tumor. Despite segmental resection, the patient died from postoperative complications, highlighting the need for multidisciplinary research into pathogenesis and management.
Fen Liu   +3 more
wiley   +1 more source

SLC7A5 promotes colorectal cancer liver metastasis by reprogramming tryptophan metabolism through the Kyn/XANA‒AhR axis and reshaping the immune microenvironment

open access: yesClinical and Translational Medicine, Volume 16, Issue 8, August 2026.
SLC7A5‒Kyn/XANA signalling activates AhR to drive EMT and metastatsis. SLC7A5 knockdown enhances macrophage antigen presentation and reverses CD8+ T‐cell exhaustion. SLC7A5 knockdown induces antigen‐driven and IgG‐secreting B‐cell clonal expansion. Combination of SLC7A5 inhibition and anti‐PD‐1 therapy offers clinical targeting.
Yaohao Luo   +8 more
wiley   +1 more source

Level of Vascular Ligation for Sigmoid Colon Cancer: Does It Matter? The Pina Low‐T Study

open access: yesJournal of Surgical Oncology, Volume 134, Issue 2, Page 263-271, August 2026.
ABSTRACT Background and Methods In sigmoid colon cancer surgery, the inferior mesenteric artery (IMA) can be ligated at its origin (high ligation, HLG) or distal to the left colic artery bifurcation (low ligation, LLG). While high ligation facilitates lymph node harvest and mobilization, it may compromise colonic perfusion and increase nerve injury ...
Silvia Picotto   +7 more
wiley   +1 more source

Uptake and Transport of Monotropein and Monotropein Esters in a Caco‐2/HT29‐MTX‐E12 Co‐Culture Model

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.
Monotropein and its naturally occurring ester derivatives (monotropein‐10‐coumarate and monotropein‐10‐cinnamate) from Gaultheria spp. berries exhibit limited intestinal permeability in a validated Caco‐2:HT29‐MTX‐E12 co‐culture model. Absorption occurs predominantly via passive diffusion, with partial SGLT1‐ and OATP‐mediated uptake contribution for ...
Christian Zielinski   +7 more
wiley   +1 more source

Ultrasmall Cyclodextrin‐Based Nanogels as Drug Delivery Systems

open access: yesChemistryOpen, Volume 15, Issue 8, August 2026.
Cyclodextrin (CD) nanogels provide a highly effective, biocompatible platform for advanced drug delivery. These specialized networks successfully encapsulate active ingredients, significantly improving overall drug solubility. Furthermore, the resulting nanogels exhibit enhanced toxicity toward cancer cell lines compared to the parent CDs.
Andrea Cesari   +7 more
wiley   +1 more source

Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE‐A Cohort of 1.2 Million Surgeries

open access: yesActa Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Postoperative complications substantially increase morbidity, mortality and healthcare costs. Understanding prognostic factors is essential for risk stratification, targeted prevention strategies, and development of prediction models.
Anders Peder Højer Karlsen   +15 more
wiley   +1 more source

Curative Surgery for Malignant Sigmoid-Duodenal Fistula Caused by Colon Cancer: A Case Report. [PDF]

open access: yesSurg Case Rep
Aso S   +8 more
europepmc   +1 more source

Phenotypic Expansion and Molecular Implications in Recessive FUZ ‐Related Ciliopathy

open access: yesClinical Genetics, Volume 110, Issue 2, Page 236-241, August 2026.
Our patient with homozygous FUZ p.Arg234Trp, potentially altering FUZ‐CPLANE2 interactions, presented with aorto‐pulmonary window, Hirschsprung disease, and shared phenotypes with previously reported ciliopathy patients. This report provides additional evidence for FUZ as a causative gene for ciliopathy, offering novel insights into the phenotype ...
Yosuke Ogawa   +4 more
wiley   +1 more source

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