Results 271 to 280 of about 1,279,401 (299)

Human umbilical cord mesenchymal stem cells alleviate colon epithelial apoptosis in ulcerative colitis by activating inositol-requiring enzyme 1/X-box binding protein 1 signaling. [PDF]

Stem Cells Transl Med
Zhao T, Hou W, Wang M, Feng Z, Feng X, Wang H, Zhao H, Li X, Hou S, Zheng G, Zhang X, Xie J.   +11 more
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Investigating the potential selective effects of a Kiperin multi-component magnesium supplement on colon cancer and normal cells. [PDF]

Sci Rep
Batur LK, Yavas C, Polat Y.
europepmc   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

The impact of primary tumor location of colorectal cancer on the survival outcome of patients with brain metastasis: a systematic review and meta-analysis. [PDF]

Eur J Med Res
Tsai TC, Atwan H, Yim C, Song J, Memon RS, Fahimuddin M, Gong C, Chang Y, Kumar A.   +8 more
europepmc   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Activated notch signaling pathway protects the intestinal barrier in DSS-induced colitis by regulating tight junctions. [PDF]

Eur J Med Res
Li T, Geng C, Li X, Song S, Li Y, Wang C.   +5 more
europepmc   +1 more source

Effects of Defined Pig Microbiota on Acute Salmonellosis in Gnotobiotic Piglets. [PDF]

FASEB J
Splichal I, Polakova K, Sinkora M, Neuzil Bunesova V, Modrackova N, Vlkova E, Kindlova Z, Horvathova K, Splichalova A.   +8 more
europepmc   +1 more source

Single-cell RNA sequence analysis reveals USP32 as a therapeutic target to mitigate PD-L1-driven colorectal tumorigenesis <i>in vitro</i> and <i>in vivo</i>. [PDF]

Theranostics
Birappa G, Perumalsamy H, Hong SH, Gowda DAA, Chandrasekaran AP, Karapurkar JK, Rajkumar S, Balusamy SR, Jayachandran A, Baek KH, Lee J, Matam V, Kim WJ, Kim KS, Ramakrishna S, Suresh B.   +15 more
europepmc   +1 more source

Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer

Mengya Niu, Yihan Pei, Tiantian Jin, Jun-Xiu Li, Liming Bai, Cuixia Zheng, Qingling Song, Hongjuan Zhao, Yun Zhang, Lei Wang   +9 more
openalex   +1 more source