Results 131 to 140 of about 5,799,531 (403)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention

BMJ Open Gastroenterology, 2017
Objective The colonic microbiota is altered in patients with colorectal cancer (CRC). We investigated the microbiota composition of patients with colon cancer compared with controls devoid of neoplastic or inflammatory disease and the potential to modify
A. Hibberd, Anna Lyra, A. Ouwehand, P. Rolny, H. Lindegren, L. Cedgård, Y. Wettergren   +6 more
semanticscholar   +1 more source

ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer

BMC Cancer, 2018
Background Metastasis is the main cause of death in patients with advanced stage colon cancer. Epithelial mesenchymal transition (EMT) plays an important role in invasion and metastasis.
Zhijun Zeng, Hao Yang, Shuai Xiao
doaj   +1 more source

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent [PDF]

, 2018
Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (
Ahmed, Shafi, Broad, John, Carroll, Rebecca, Chin-Aleong, Joanne, Darreh-Shori, Taher, Elahi, Shezan, Karami, Azadeh, Knowles, Charles H., Kung, Victor W. S., Martin, Joanne E., Palmer, Alexandra, Saffrey, M. Jill, Sanger, Gareth John, Thaha, Mohamed Adhnan   +13 more
core   +2 more sources

Discovery of Orally Bioavailable N-Benzylpiperidinol Derivatives as Potent and Selective USP7 Inhibitors with In Vivo Antitumor Immunity Activity against Colon Cancer

, 2022
Xing Li, Shanlin Yang, Honghan Zhang, Xipeng Liu, Yuchen Gao, Yuqi Chen, Liu Liu, Dalin Wang, Zijiang Liang, Shengjie Liu, Liang Dai, Qing‐Long Xu, Haoliang Yuan, Caiping Chen, Hongbin Sun, Xiaoan Wen   +15 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Immune cell infiltration as a biomarker for the diagnosis and prognosis of stage I–III colon cancer

Cancer Immunology and Immunotherapy, 2018
Tumour-infiltrating immune cells are a source of important prognostic information for patients with resectable colon cancer. We developed a novel immune model based on systematic assessments of the immune landscape inferred from bulk tumor transcriptomes
R. Zhou, Jingwen Zhang, D. Zeng, Huiying Sun, Xiaoxiang Rong, Min Shi, J. Bin, Y. Liao, W. Liao   +8 more
semanticscholar   +1 more source

Screening of Differentiation-Specific Molecular Biomarkers for Colon Cancer

Cellular Physiology and Biochemistry, 2018
Background/Aims: Owing to the lack of effective molecular markers to evaluate colon cancer differentiation grade, screening of effective molecular markers for the diagnosis and treatment of colon cancer is of great significance. This study is a screening
Lu Qi, Yanqing Ding
doaj   +1 more source

Anticancer effect of tectochrysin in colon cancer cell via suppression of NF-kappaB activity and enhancement of death receptor expression [PDF]

, 2015
BACKGROUND: Flavonoids are a diverse family of natural phenolic compounds commonly found in fruits and vegetables. Epidemiologic studies showed that flavonoids also reduce the risk of colon cancer.
Bang Yeon Hwang, Byung Kook Hyun, Doo Won Seo, Eun Sook Park, Hee Sung Yoon, Ji Eun Hong, Jin Tae Hong, Mi Hee Park, Sang-Bae Han, Young Won Ham   +9 more
core   +1 more source