Results 171 to 180 of about 5,799,531 (403)

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Advanced Healthcare Materials, EarlyView.
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers   +10 more
wiley   +1 more source

Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short‐ and Long‐Lived Radicals

Advanced Healthcare Materials, EarlyView.
Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski, Maciej Studzian, Szymon Lekki‐Porebski, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko, Lukasz Pulaski   +6 more
wiley   +1 more source

Cancer-related multiple brain infarctions caused by Trousseau syndrome in a patient with metastatic colon cancer: a case report [PDF]

, 2016
Takahiko Akiyama, Yuji Miyamoto, Yasuo Sakamoto, Ryuma Tokunaga, Keisuke Kosumi, Hironobu Shigaki, Junji Kurashige, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hideo Baba   +10 more
openalex   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Establishment and characterization of a sigmoid colon cancer organoid with spinal metastasis

Frontiers in Cell and Developmental Biology
BackgroundSigmoid colon cancer with spinal metastases is rare in distant metastasis. In addition, the prognosis of colon cancer patients with spinal metastases is extremely poor.
Jingyao Chen, Jingyao Chen, Shumin Cheng, Liang Gu, Liang Gu, Zhangsen Huang, Zhangsen Huang, Changhua Zhang, Changhua Zhang, Chunhui Sun, Chunhui Sun, Chunhui Sun, Songyao Chen, Songyao Chen   +13 more
doaj   +1 more source

Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer

, 2012
Batool Akhtar‐Zaidi, Richard Cowper‐Sal·lari, Olivia Corradin, Alina Saiakhova, Cynthia F. Bartels, Dheepa Balasubramanian, Lois L. Myeroff, James Lutterbaugh, Awad Jarrar, Matthew F. Kalady, Joseph Willis, Jason H. Moore, Paul J. Tesar, Thomas LaFramboise, Sanford D. Markowitz, Mathieu Lupien, Peter C. Scacheri   +16 more
openalex   +2 more sources

Simultaneous Robot Assisted Colon and Liver Resection for Metastatic Colon Cancer [PDF]

, 2021
Matthew McGuirk, Mahir Gachabayov, Aram Rojas, Agon Kajmolli, Shekhar Gogna, Katie Gu, Qian Qiuye, Xiang Da Dong   +7 more
openalex   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Colon Cancer

Menon G, Cagir B.
europepmc   +2 more sources