Results 231 to 240 of about 1,115,426 (335)

Loss of Golga7 Suppresses Oncogenic Nras‐Driven Leukemogenesis without Detectable Toxicity in Adult Mice

Advanced Science, EarlyView.
NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao, Lei Yan, Rui Zhang, Wei Huang, Xinru Wang, Chenxuan Liu, Peihong Wang, Pengfei Xu, Jinzeng Wang, Zhou Fang, Donghe Li, Zhizhou Xia, Jiaoyang Li, Shiyu Ji, Qianqian Zhang, Min Wu, Shengyue Wang, Ping Liu, Ruibao Ren   +18 more
wiley   +1 more source

Identification of Senescence-Related Genes for the Prediction of Ulcerative Colitis Based on Interpretable Machine Learning Models. [PDF]

J Inflamm Res
Ma J, Chen C, Wang N, Fang T, Liu Y, He P, Dong W.   +6 more
europepmc   +1 more source

Neuropeptide Ecdysis‐Triggering Hormone and Its Receptor Mediate the Fecundity Improvement of ‘Candidatus Liberibacter Asiaticus’‐Infected Diaphorina citri Females and CLas Proliferation

Advanced Science, EarlyView.
In CLas‐infected D. citri, CLas lowers 20E levels initially, relieving the suppression of ETH release. The subsequent increase in ETH levels upregulates its receptor DcETHR and activates the JH signaling pathway. The signaling cascade of 20E‐ETH/ETHR‐JH along with miR‐210, targeting DcETHR, boost female fecundity in CLas+ D.
Xiaoge Nian, Bo Wang, Paul Holford, George Andrew Charles Beattie, Shijian Tan, Weiwei Yuan, Yijing Cen, Yurong He, Songdou Zhang   +8 more
wiley   +1 more source

Effect of <i>Lactiplantibacillus plantarum</i> DSW3805 Isolated from Kimchi for Gut Health Attenuating Colonic Inflammation in a Dextran Sulfate Sodium-Induced Mouse Model. [PDF]

Nutrients
Lee NK, Lee Y, Shin DS, Choi YM, Lee J, Park E, Paik HD.   +6 more
europepmc   +1 more source

Low‐Irradiance Antimicrobial Blue Light‐Bathing Therapy for Wound Infection Control

Advanced Science, EarlyView.
Antimicrobial blue light has been shown as an appealing non‐pharmacological antimicrobial alternative. However, its clinical applications have been hindered by high irradiance‐associated photothermal risks. In this work, a low‐irradiance blue light‐bathing concept and a wearable photonic wound patch are established to address this challenge in terms of
Jie Hui, Wonjoon Moon, Pu‐Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, R. Rox Anderson, Jeremy Goverman, Jeffrey A. Gelfand, Seok‐Hyun Yun   +12 more
wiley   +1 more source

Dietary prevention of antibiotic-induced dysbiosis and mortality upon aging in mice. [PDF]

FASEB J
Smith KM, Francisco SG, Zhu Y, LeRoith T, Davis ML, Crott JW, Barger K, Greenberg AS, Smith DE, Taylor A, Yeruva L, Rowan S.   +11 more
europepmc   +1 more source

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

Cucurbitacin IIa Alleviates Colitis via Promoting the Release of Host-Derived Extracellular Vesicles Encapsulating microRNA-30b-5p. [PDF]

J Inflamm Res
Zhao Y, Jiang B, Zuo S.
europepmc   +1 more source

Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng, Xin Yang, Jiani Sun, Ximing Ran, Dan Zhou, Mingming Ye, Li Wen, Ruirui Wang, Miaoxin Chen   +8 more
wiley   +1 more source

Role of Simulated Nannochloropsis gaditana Digests in Shaping Gut Microbiota and Short-Chain Fatty Acid Levels. [PDF]

Nutrients
Paterson S, Majchrzak M, Gómez-Garre D, Ortega-Hernández A, Sánchez-González S, de la Fuente MÁ, Gómez-Cortés P, Hernández-Ledesma B.   +7 more
europepmc   +1 more source