Results 101 to 110 of about 247,377 (298)

Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release [PDF]

, 2019
In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring multi-drug resveratrol (RES). Such systems are endowed with potential therapeutic effects on inflammatory bowel diseases (IBD), such as ...
Benito Hernández, Elena María, Díaz Blanco, Manuel Jesús, Galbis Fuster, Elsa, Iglesias, N., Lucas Rodríguez, Ricardo, Paz Báñez, María Violante de   +5 more
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Frequency of Thyroid Nodules among Patients with Colonic Polyps

Gastroenterology Research and Practice, 2012
Aim. Colonic polyps and thyroid nodules are common diseases and their frequency increases with age. In the literature, there is no study investigating the coexistence of colonic polyps and thyroid nodules.
Cevdet Duran, Huseyin Savas Gokturk, Mustafa Kulaksizoglu, Suleyman Bakdik, Gulhan Kanat Unler, Mustafa Erbayrak, Guven Ozkaya, Baris Onder Pamuk, Mustafa Sait Gonen   +8 more
doaj   +1 more source

Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes [PDF]

, 2017
Background: Physical exercise has been reported to increase the bioavailability of citrus flavanones. Objective: To investigate the bioavailability of orange juice (OJ) (poly)phenols in endurance-trained men before and after cessation of training for 7 ...
Crozier, Alan, Garcia, Ada L., Ludwig, Iziar A., Malkova, Dalia, Moreno-Rojas, Manuel, Natase, Ana-Maria, Pereira-Caro, Gema, Polyviou, Thelma   +7 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Protective and therapeutic potentials of Trichinella spiralis larval antigen in murine induced colitis

Scientific Reports
The intolerable side effects and clinical limitations of current conventional therapies for inflammatory bowel diseases (IBDs), there is a pressing need for alternative treatment options.
Enas A. M. Huseein, Samia S. Alkhalil, Hanan S. M. Farghaly, Haiam M. M. Farrag, Hanaa Y. Bakir, Noha M. Aboulhagag, Samah S. M. Mohamed, Mona Gaber   +7 more
doaj   +1 more source

Prevalence of pks-positive Escherichia coli in Japanese patients with or without colorectal cancer

Gut Pathogens, 2017
Background Recent studies show that some Escherichia coli strains possessing a gene cluster named the pks island might have a causative role in the development of human colorectal cancer (CRC).
Takayuki Shimpoh, Yoshihiro Hirata, Sozaburo Ihara, Nobumi Suzuki, Hiroto Kinoshita, Yoku Hayakawa, Yumiko Ota, Akiko Narita, Shuntaro Yoshida, Atsuo Yamada, Kazuhiko Koike   +10 more
doaj   +1 more source

Dietary calcium decreases but short-chain fructo-oligosaccharides increase colonic permeability in rats [PDF]

, 2010
An increased intestinal permeability is associated with several diseases. Nutrition can influence gut permeability. Previously, we showed that dietary Ca decreases whereas dietary short-chain fructo-oligosaccharides (scFOS) increase intestinal ...
Bovee-Oudenhoven, I.M.J., Brummer, R.J.M., Meer, R., van de, Rijnierse, A., Schepens, M.A.A., Schonewille, A.J., Vink, C., Willemsen, L.E.M.   +7 more
core   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

An Ano-recto-sigmoidoscopic Study in Colonic Diseases

Eurasian Journal of Medicine, 2019
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Ahmet Yıldız, Faruk Memik
doaj