Results 111 to 120 of about 247,377 (298)

Clinical analysis and identification of pediatric patients with colonic ulceration

BMC Pediatrics
Background A wide variety of diseases mimic inflammatory bowel disease (IBD). This study aimed to reduce the misdiagnosis among children with colonic ulcers.
Yaying You, Yijing Tao, Yanwen Xu, Yi Cao, Haixia Feng, Qingqing Wu, Ying Wang, Weihui Yan   +7 more
doaj   +1 more source

Microbial pathways in colonic sulfur metabolism and links with health and disease

Frontiers in Physiology, 2012
Sulfur is both crucial to life and a potential threat to health. While colonic sulfur metabolism mediated by eukaryotic cells is relatively well studied, much less is known about sulfur metabolism within gastrointestinal microbes.
Franck eCarbonero, Ann C. Benefiel, Amir H. Alizadeh-Ghamsari, H. Rex eGaskins, H. Rex eGaskins, H. Rex eGaskins, H. Rex eGaskins, H. Rex eGaskins   +7 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. [PDF]

, 2019
Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions ...
Akiba, Yasutada, Iwasaki, Mari, Kaunitz, Jonathan D   +2 more
core  

PET/CT incidental detection of second tumor in patients investigated for pancreatic neoplasms [PDF]

, 2018
Positron Emission Tomography/computed tomography (PET/CT) is an imaging technique which has a role in the detection and staging malignancies (both in first diagnosis and follow-up).
Bissoli, Sergio, Fantin, Alberto, Moletta, Lucia, Passuello, Nicola, Sperti, Cosimo, Valmasoni, Michele   +5 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Prebiotic effects: metabolic and health benefits [PDF]

, 2010
The different compartments of the gastrointestinal tract are inhabited by populations of micro-organisms. By far the most important predominant populations are in the colon where a true symbiosis with the host exists that is a key for well-being and ...
Agnes Meheust, Anne L. McCartney, Audrey M. Neyrinck, Balsari, Ben, Bernd Stahl, Bernhard Watzl, Blaut, Brommage, Caderni, Caers, Cashman, Cashman, Chassard, Coudray, Cummings, Danielle Wolvers, de Vrese, Dughera, Engelhardt, Fava, Francisco Guarner, Franck, Frederique Respondek, Gibson, Girrbach, Glenn R. Gibson, Gray, Griffin, Hanai, Hania Szajewska, Harmsen, Hawthorne, Hudson, Hughes, Hussey, Ian Rowland, Irvine, Irvine, Kanauchi, Kelly, Kevin Whelan, Kim, Klobukowski, Kobayashi, Laurent Léotoing, Lesley Hoyles, Levitt, Lien do, Macfarlane, Macfarlane, Marcel Roberfroid, Marie-Jeanne Davicco, Mathey, Morand, Murphy, Nathalie M. Delzenne, Ng, O'Connor, O'May, Ohta, Ohta, Patrice D. Cani, Perrin, Pierre, Quigley, Rayssiguier, Reddy, Remesy, Reshef, Reuter, Richardson, Roberfroid, Roberfroid, Roberfroid, Roberfroid, Roberfroid, Robert Rastall, Rondon, Rowland, Sakaguchi, Schaafsma, Sellon, Siong, Suau, Taper, van Dokkum, Veronique Coxam, Vulevic, Wada, Walker, Wilson, Yohann Wittrant, Zoetendal, Zoetendal   +94 more
core   +3 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Quinoa and Colonic Health: A Review of Bioactive Components and Mechanistic Insights

Current Issues in Molecular Biology
Quinoa (Chenopodium quinoa Willd.) is an ancient Andean crop renowned for its exceptional nutritional profile and diverse bioactive compounds, including polysaccharides, polyphenols, saponins, and essential fatty acids.
Yan Pan, Jimin Zheng, Zhixuan Wang, Shaohua Lin, Hongliang Jia, Hairun Pei, Ronghui Ju   +6 more
doaj   +1 more source

Lymphoma caused by intestinal microbiota. [PDF]

, 2014
The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions ...
Schiestl, Robert H, Yamamoto, Mitsuko L
core   +2 more sources