Results 201 to 210 of about 180,490 (257)

Elucidation of the process of delayed colonic perforation after endoscopic thermal injury in a rat model. [PDF]

Sci Rep
Sakae T, Maeda H, Sasaki F, Nakamura Y, Koyoshi N, Uehara S, Tanaka A, Hinokuchi M, Arima S, Hashimoto S, Kanmura S, Ido A.   +11 more
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

MAIT Cells Maintain Intestinal Homeostasis Through IL-22 in an Experimental Colitis. [PDF]

J Inflamm Res
Peng Y, Zheng C, Wang Y, Huang F, Shao Y, Liu L, Zhao Q.   +6 more
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Network pharmacology identifies the mechanisms of action of Jianpi Yanggan Pill in treating diarrhea-predominant irritable bowel syndrome. [PDF]

Am J Transl Res
Ma K, Hua X, Li Z, Zhang S, Zhu T, Jin L, Li W, Shao J, Li X, Wen W, Luan Y.   +10 more
europepmc   +1 more source

Spondyloarthritis Associated With Collagenous Colitis-Case Report and Literature Review. [PDF]

Clin Case Rep
Bouvy C, Kapuczinski A, Ibrahimi S, Léon M, Demeulenaere N.   +4 more
europepmc   +1 more source

Endoscopic ultrasound‑guided stricturotomy for complete anastomotic occlusion following Hartmann's reversal. [PDF]

Endoscopy
Zhong Q, Feng X, Lin D, Li J, Su M, Chen Y, Guo X.   +6 more
europepmc   +1 more source

Modeling the microbial contribution to human energy balance using the Digestion, Absorption, and Microbial Metabolism (DAMM) model. [PDF]

PLoS One
Davis TL, Dirks B, Carnero EA, Corbin KD, Smith SR, Marcus A, Krajmalnik-Brown R, Rittmann BE.   +7 more
europepmc   +1 more source

XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease. [PDF]

MedComm (2020)
Fang R, Wang W, Zhang L, Huang J, Huang L, Wu H, Qi Y, Li L, Tan L, Zhang M, Zhu J, Peng X, Zhong K, Zou M, Yang X, Wang Q, Nie C, Tang C, Tang N, Geng L, Chen H, Vince JE, Kanegane H, Zhao X, Xian H, Zhou W, Zhi M, Zhang Y, Chen Z.   +28 more
europepmc   +1 more source