Results 101 to 110 of about 322,350 (298)

Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice

, 2004
BACKGROUND: Glucagon-like peptide 2 (GLP-2) is an intestinotrophic mediator with therapeutic potential in conditions with compromised intestinal capacity.
Poulsen, S S, Hare, K J, Hartmann, B, Kissow, H, Holst, Jens Juul, Thulesen, J, Ørskov, C   +6 more
core   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Serous Neoplasms

, 2014
Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example.
D'ONOFRIO, Mirko, Paolo Tinazzi Martini, Giovanni Morana, Stefano Canestrini, Riccardo De Robertis, Roberto Pozzi Mucelli, Capelli, Paola, MORANA, Giovanni, Paola Capelli, Stefano Gobbo, DE ROBERTIS LOMBARDI, Riccardo, Martini, Paolo Tinazzi, GOBBO, Stefano, CANESTRINI, Stefano, LUCHINI, Claudio, Mirko D’Onofrio, Claudio Luchini, POZZI MUCELLI, Roberto   +17 more
core   +1 more source

Urachal Mucinous Cystic Tumor of Low Malignant Potential with Concurrent Sigmoid Colon Adenocarcinoma

Case Reports in Gastrointestinal Medicine, 2019
Urachal mucinous tumors are rare neoplasms with behaviour that can range from relatively benign to malignancy that can spread distantly or throughout the peritoneum as pseudomyxoma peritonei or peritoneal carcinomatosis. Here we describe a unique case of
Kelly Brennan, Paul Johnson, Heather Curtis, Thomas Arnason   +3 more
doaj   +1 more source

Cystic Lymphangioma of the Colon: Endoscopic Removal beyond the Frontiers of Size

Case Reports in Gastroenterology, 2017
Cystic lymphangiomas are benign colonic neoplasms arising from the submucosa. Traditionally, endoscopic resection has been described for smaller lesions, while surgery is reserved for larger symptomatic lesions.
Kanthi Rekha Badipatla, Chaitanya Chandrala, Puvanalingam Ayyadurai, Madhavi Biyyam, Binita Sapkota, Masooma Niazi, Suresh Kumar Nayudu   +6 more
doaj   +1 more source

Clonal Composition of Human Adrenocortical Neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Travis, W., Beuschlein, Felix, Karl, M., Chrousos, G. P., Abdelhamid, S., Allolio, B., Jaursch-Hancke, C., Reincke, Martin   +7 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Assessment of JC Polyoma Virus in Colon Neoplasms

Diseases of the Colon & Rectum, 2005
Research data have recently emphasized an intriguing association of JC polyoma virus with colon carcinogenesis. Tumorigenicity of JC virus is attributed to the T-antigen of its Mad-1 variant. Controversy arose when another research group did not confirm this association.
Theodoropoulos, G, Panoussopoulos, D, Papaconstantinou, I, Gazouli, M, Perdiki, M, Bramis, J, Lazaris, AC   +6 more
openaire   +3 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source