Results 271 to 280 of about 185,360 (305)

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

A colonic lipoma presenting as intussusception in an elderly patient. [PDF]

Radiol Case Rep
Lahlou N, Bouardi NE, Ettylemsany Z, Ouazzani H, Chaouche I, Akammar A, Haloua M, Alami B, Lamrani MYA, Boubbou M, Maaroufi M.   +10 more
europepmc   +1 more source

Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release

Advanced Science, EarlyView.
The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu   +17 more
wiley   +1 more source

Ileal J-Pouch interposition as a salvage technique for failed coloanal anastomosis: a case report. [PDF]

BMC Surg
Derakhshani S, Ghadim MK, Ashtari S.
europepmc   +1 more source

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Simultaneous Gastric Cancer Metastases to the Small and Large Intestines: Hidden Small Intestinal Lesions and Colonic-Mimicking Metastases. [PDF]

Surg Case Rep
Nakamura S, Yamamoto M, Nakamura T, Tateishi Y, Sakada R, Nagashima S, Morita K, Higashi H, Yoshizumi T.   +8 more
europepmc   +1 more source

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

Advanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li, Ping Deng, Tengfei Fan, Yuchen Qu, Miduo Tan, Yidan Liang, Peng Gao, Yongchun Peng, Mingke Qin, Sheng Jie, Rongrong Hao, Liting Wang, Lei Zhang, Chunhai Chen, Mindi He, Qinlong Ma, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Rui Tian, Min Li, Zhengping Yu, Zhou Zhou, Huifeng Pi   +24 more
wiley   +1 more source

Short-Term Efficacy and Long-Term Limitations of Self-Expandable Metallic Stent Placement for Colorectal Obstruction due to Extracolonic Malignancies. [PDF]

DEN Open
Yamamoto M, Osugi N, Nakamatsu D, Matsumoto K, Fukui K, Nishida T.   +5 more
europepmc   +1 more source

Gastrointestinal metastasis from invasive lobular carcinoma following breast cancer treatment: A case report. [PDF]

World J Clin Cases
Liu PP, Sun LL, Jing X.
europepmc   +1 more source

Metastatic colon involvement from primary adrenal gland angiosarcoma: a case report. [PDF]

J Med Case Rep
Ben Rejeb S, Sakly S, Bahloul R, Jomni T, Dridi K.   +4 more
europepmc   +1 more source