Results 51 to 60 of about 229,210 (273)

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation‐Associated Paraptosis‐Like Cell Death in Colorectal Cancer

Advanced Science, EarlyView.
This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song, Sikei Kam, Jingyi Liu, Rui Lv, Xucheng Huo, Zhanghan Chen, Yuelun Dong, Shilun Cai, Bing Li, Ruobing Ren, Yunshi Zhong, Mingyan Cai   +11 more
wiley   +1 more source

Single‐cell landscape of the cellular microenvironment in three different colonic polyp subtypes in children

Clinical and Translational Medicine
Background The understanding of the heterogeneous cellular microenvironment of colonic polyps in paediatric patients with solitary juvenile polyps (SJPs), polyposis syndrome (PJS) and Peutz–Jeghers syndrome (PJS) remains limited.
Yafei Deng, Canlin Li, Lanlan Huang, Peiwen Xiong, Yana Li, Yongjie Liu, Songyang Li, Weijian Chen, Qiang Yin, Yong Li, Qinglan Yang, Hongyan Peng, Shuting Wu, Xiangyu Wang, Qin Tong, Hongjuan Ouyang, Die Hu, Xinjia Liu, Liping Li, Jieyu You, Zhiyi Sun, Xiulan Lu, Zhenghui Xiao, Youcai Deng, Hongmei Zhao   +24 more
doaj   +1 more source

KRAS and BRAF somatic mutations in colonic polyps and the risk of metachronous neoplasia. [PDF]

PLoS ONE, 2017
High-risk features of colonic polyps are based on size, number, and pathologic characteristics. Surveillance colonoscopy is often recommended according to these findings. This study aimed to determine whether the molecular characteristics of polyps might
Miriam Juárez, Cecilia Egoavil, María Rodríguez-Soler, Eva Hernández-Illán, Carla Guarinos, Araceli García-Martínez, Cristina Alenda, Mar Giner-Calabuig, Oscar Murcia, Carolina Mangas, Artemio Payá, José R Aparicio, Francisco A Ruiz, Juan Martínez, Juan A Casellas, José L Soto, Pedro Zapater, Rodrigo Jover   +17 more
doaj   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

First Case Report of Turcot Syndrome Type 1 in Colombia

Case Reports in Oncological Medicine, 2012
Turcot syndrome is an autosomal recessive disorder clinically characterized by the occurrence of primary tumors of the central nervous system and adenomatous colonic polyps during the first or second
Vallejo Dora, Garnica Diego, Bonilla Rómulo, Olaya Natalia   +3 more
doaj   +1 more source

Results of total colonoscopy in the diagnosis of polyps. Case studies in Villavicencio, Colombia

Revista de la Facultad de Medicina, 2017
Introduction: Any elevation above the normal plane of the colonic mucosa is considered a polypoid projection. As age increases, polyps are more likely to be found; in addition, polyps larger than 1 cm of diameter may potentially lead to a malignant ...
Mauricio Alberto Melo-Peñaloza
doaj   +1 more source

Accuracy of i-Scan for Optical Diagnosis of Colonic Polyps: A Meta-Analysis. [PDF]

PLoS ONE, 2015
i-Scan is a novel virtual chromoendoscopy system designed to enhance surface and vascular patterns to improve optical diagnostic performance. Numerous prospective studies have been done to evaluate the accuracy of i-Scan in differentiating colonic ...
Chuan-Guo Guo, Rui Ji, Yan-Qing Li
doaj   +1 more source

A novel technique using endoscopic band ligation for removal of long-stalked (>10 mm) pedunculated colon polyps: A prospective pilot study

The Saudi Journal of Gastroenterology, 2021
Background: Endoscopic removal of large and thick-stalked pedunculated colonic polyps, often leads to massive hemorrhage. Several techniques to minimize this complication have not been widely adopted due to some caveats.
Hyun Ho Choi, Chang Whan Kim, Hyung-Keun Kim, Sang Woo Kim, Sok Won Han, Kyung Jin Seo, Hiun-Suk Chae   +6 more
doaj   +1 more source