Results 91 to 100 of about 392,683 (226)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
A Quintas-Cardama, A Quintas-Cardama, A Quintas-Cardama, AJ Tipping, AJ Tipping, B Zhang, C Akgul, C Bellodi, G Gurel, H de Lavallade, H Konig, HG Jorgensen, HM Kantarjian, J Kuroda, KJ Aichberger, L Legros, M Copland, M Copland, NB Heaney, R Chen, R Tang, RG Powell, RM Stone, S Chu, SM Graham, SV Sharma, T Kobayashi, Y Chen   +27 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A New Automatic System Of Cell Colony Counting

, 2006
The counting process of cell colonies is always a long and laborious process that is dependent on the judgment and ability of the operator. The judgment of the operator in counting can vary in relation to fatigue. Moreover, since this activity is time consuming it can limit the usable number of dishes for each experiment.
Bottigli, U., Carpinelli, M., Fiori, P. L., Golosio, B., Marras, A., Masala, G. L., Oliva, P.   +6 more
openaire   +8 more sources

Networking strategies in streptomyces coelicolor [PDF]

, 2009
We are interested the soil dwelling bacteria Streptomyces coelicolor because its cells grow end to end in a line. New branches have the potential to extend from any point along this line and the result is a network of branches and connections.
Gaze, William H., Griffiths, Nathan, Kalvala, Sara, Rossello, M. R., Wellington, E. M. H.   +4 more
core  

Resuscitation and quantification of stressed Escherichia coli K12 NCTC8797 in water samples [PDF]

, 2009
The aim of this study was to investigate the impact on numbers of using different media for the enumeration of Escherichia coli subjected to stress, and to evaluate the use of different resuscitation methods on bacterial numbers. E. coli was subjected to
Bissonnette, Bissonnette, Bjergbaek, Byrd, Colwell, Darcan, Davies, Dukan, E. Kariptas, F. Saribiyik, Flint, Gameson, Herson, Hobbie, Jannasch, Jones, K. Isik, K.P. Flint, LeChevallier, Lim, McCleery, McFeters, Means, N. Sahin, Nilsson, Pagel, R. Özkanca, Ray, Reissbrodt, Roszak, Roszak, Tabor, Tillett, White, Xu, Özkanca, Özkanca, Özkanca   +37 more
core   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Quantification methods of Candida albicans are independent irrespective of fungal morphology

Microbial Cell
The ability of Candida albicans to switch its morphology from yeast to filaments, known as polymorphism, may bias the methods used in microbial quantification.
Amanda B Soares, Maria C de Albuquerque, Leticia M Rosa, Marlise I Klein, Ana C Pavarina, Paula A Barbugli, Livia N Dovigo, Ewerton G de O Mima   +7 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The 'Foce' monumental cemetery in Sanremo: mirror of the city as outstanding tourist destination during the Belle Epoque (1880-1915) [PDF]

, 2015
The monumental cemetery of Sanremo, was founded in 1838 and now counts about 2000 graves, one third of which belongs to foreigners, evidences of the city as outstanding tourist destination.
Salvini, Silvia
core   +2 more sources