Results 71 to 80 of about 392,683 (226)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A comparison of the antimicrobial efficacy of silver diamine fluoride and silver nitrate: an in vitro study [PDF]

, 2018
A COMPARISON OF THE ANTIMICROBIAL EFFICACY OF SILVER DIAMINE FLUORIDE AND SILVER NITRATE: AN IN VITRO STUDY By: Nicholas L Luke, D.D.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at ...
Luke, Nicholas L
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Antimicrobial efficacy of chlorine dioxide against Candida albicans in stationary and starvation phases in human root canal: An in-vitro study

Sahel Medical Journal, 2014
Introduction: Candida albicans (C. albicans) is the most commonly isolated fungal pathogen from dental root canal. C. albicans forms biofilm and develops resistance against root canal irrigants .
Shirur Krishnaraj Somayaji, Shobha Karabylu Lakshminarayana, Mohandas Rao Kappettu Gadahad   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Evaluation of bacterial and fungal contamination of kitchens of Birjand University of Medical Sciences

BMC Research Notes, 2019
Objective This study aims to evaluate the total bacterial and fungal count of tools, devices and surfaces of kitchens of the centers affiliated to Birjand University of Medical Sciences. In this study, 200 samples from four kitchens of Birjand University
Seyyedeh Masoomeh Rahimi, Maryam Ebrahimi, Behnam Barikbin, Tayebeh Zeinali   +3 more
doaj   +1 more source

Distributed House-Hunting in Ant Colonies

, 2015
We introduce the study of the ant colony house-hunting problem from a distributed computing perspective. When an ant colony's nest becomes unsuitable due to size constraints or damage, the colony must relocate to a new nest.
Ghaffari, Mohsen, Lynch, Nancy, Musco, Cameron, Radeva, Tsvetomira   +3 more
core   +1 more source

Local host response following an intramammary challenge with Staphylococcus fleurettii and different strains of Staphylococcus chromogenes in dairy heifers [PDF]

, 2016
Coagulase-negative staphylococci (CNS) are a common cause of subclinical mastitis in dairy cattle. The CNS inhabit various ecological habitats, ranging between the environment and the host.
A Harada, A Sipka, A Visscher De, A Visscher De, Anneleen De Visscher, C Mollet, C Riollet, DD Bannerman, DD Bannerman, FN Souza, Freddy Haesebrouck, G Braem, H Simojoki, H Simojoki, J Mehrzad, J Verbeke, Joren Verbeke, JS Hogan, JY Park, K Breyne, K Jensen, K Oostveldt Van, K Oostveldt Van, K Piccart, K Supré, K Supré, KP Waller, Kristine Piccart, M Haveri, MK Whyte, OC Sampimon, OC Sampimon, P Boutet, PR Fry, S Piepers, S Pyörälä, S Taponen, S Taponen, S Vliegher De, S Vliegher De, Sarne De Vliegher, SC Nickerson, Sofie Piepers, T Tomazi, V Piessens, W Vanderhaeghen, WC Liles, YH Schukken   +47 more
core   +5 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Impact of wild-type and genetically modified Pseudomonas fluorescens on soil enzyme activities and microbial population structure in the rhizosphere of pea [PDF]

, 1998
The definitive version is available at www.blackwell-synergy.com. Copyright Blackwell Publishing DOI : 10.1046/j.1365-294x.1998.00367.xThe aim of this work was to determine the impact of wild type along with functionally and non-functionally modified ...
D. C. NASEBY, De Leij FAAM, Doyle JD, Fenton AM, J. M. LYNCH, Jones RA, Morgan JAW, Shanahan P   +7 more
core   +1 more source