Results 201 to 210 of about 160,344 (260)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Combined treatment with bacteriophages and sodium hypochlorite against <i>E. faecalis</i> biofilm in an <i>in vitro</i> root canal model with evaluation of bacterial resistance. [PDF]

J Oral Microbiol
Steffen K, Bitter K, Schlafer S, Paris S, Bauer M.   +4 more
europepmc   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Meox1 promotes hepatocellular carcinoma progression potentially via regulation of cell cycle and p21 expression. [PDF]

Cell Adh Migr
Ruan J, Xie Y, Zhang C, Sun D.
europepmc   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Tumor Treating Fields (TTFields), and their concomitant application with FOLFOX, are effective for the treatment of gastric cancer cells. [PDF]

Front Oncol
Fishman H, Ene HM, Zeevi E, Flint-Brodsly N, Wainer-Katsir K, Frechtel-Gerzi R, Martinez-Conde A, Greenstein S, Dor-On E, Munster M, Porat Y, Voloshin T, Davidi S, Lavy-Shahaf G, Haber A, Giladi M, Weinberg U, Palti Y.   +17 more
europepmc   +1 more source

Fluvalinate accumulation in the beehive environment and its effects on semen quality and gene expression of drones under field conditions. [PDF]

Ecotoxicology
Ratvaj M, Staroň M, Sabo R, Kňazovická V, Cingeľová Maruščáková I, Mudroňová D, Maďar M, Staroňová D, Sabová L, Majchrák T.   +9 more
europepmc   +1 more source

Successful conversion therapy for presumed granulocyte colony-stimulating factor-producing hepatocellular carcinoma: a case report. [PDF]

Front Oncol
Chen Q, Chen T, Zhang X, Zhang M.
europepmc   +1 more source

Febrile neutropenia adversely affects chemomobilization outcomes in patients with multiple myeloma and increases risk for post-transplant infection in those with lymphoma: real-world multicenter data. [PDF]

Blood Sci
Qian H, Wang X, Yang L, Peng J, Zhao J, He S, Zhao J, Guo J, Fang Y, Meng F, Cao Y, Huang L, Wei J, Ma L, Su L, Tian W, Zhang Y, Wei J.   +17 more
europepmc   +1 more source

Antimicrobial effects of Propolis, calcium Hydroxide, triple antibiotic paste, and modified triple antibiotic paste on tubular dentin inoculated with a dual-species biofilm: an ex vivo study. [PDF]

BMC Oral Health
Ahangari Z, Zargar N, Pourhajibagher M, Shahhosseini R.   +3 more
europepmc   +1 more source