Results 41 to 50 of about 160,344 (260)

Microbial Safety of Black Summer Truffle Collected from Sicily and Umbria Regions, Italy

Journal of Food Quality and Hazards Control, 2021
Background: Tuber aestivum Vittad., known as black summer truffle, represents high-value food especially used as garnishment in nouvelle cuisine. The aim of this study was to investigate on the viable microbial populations associated with T.
F. Cirlincione, N. Francesca, L. Settanni, D. Donnini, G. Venturella, M.L. Gargano   +5 more
doaj  

Curcumin Effects in Inducing mRNA Gene Cathelidicin Antimicrobial Peptide (CAMP) in Balb/c Mice Infected with Salmonella Typhi

Journal of Biological Research, 2020
Due to many cases of antibiotic resistance in typhoid fever, efforts have been made to combine antibiotic therapy or active compounds with herbs. Curcumin is an active compound found in herbal plants. Curcumin has an antimicrobial effect; through binding
Ami Febriza, Rosdiana Natzir, Mochammad Hatta, Cuno S.P.M Uiterwaal, Suryani As'ad, Budu Budu, Gemini Alam, Vivien Novarina Kasim, Hasta Handayani Idrus   +8 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Environmental hygiene and healthcare-associated infection: a time-series study based on generalized additive model

Frontiers in Public Health
ObjectiveTo quantitatively analyze the impact of environmental hygiene on the occurrence of healthcare-associated infection (HAI).MethodsMonitoring data of HAI and environmental hygiene from a tertiary first-class hospital from July 1, 2022, to December ...
Renhua Li, Zhongjie Wang, Mingqi Huang, Daiying Liao, Zhe Yuan, Keli Qian   +5 more
doaj   +1 more source

Comparison between adenosine triphosphate bioluminescence and aerobic colony count to assess surface sanitation in the hospital environment

Epidemiology, Biostatistics and Public Health, 2022
Background: Adenosine triphosphate bioluminescence produced by the firefly luciferase has been successfully introduced to verify cleaning procedures in the food industry according to the Hazard Analysis Critical Control Point program.
Daniele Domenico Raia, Lucia Cannova, Sandro Provenzano, Omar Enzo Santangelo, Dario Piazza, Enrico Alagna, Valentina Bonanno, Luigi Aprea, Alberto Firenze   +8 more
doaj   +1 more source

A New Automatic System Of Cell Colony Counting

, 2006
The counting process of cell colonies is always a long and laborious process that is dependent on the judgment and ability of the operator. The judgment of the operator in counting can vary in relation to fatigue. Moreover, since this activity is time consuming it can limit the usable number of dishes for each experiment.
Bottigli, U., Carpinelli, M., Fiori, P. L., Golosio, B., Marras, A., Masala, G. L., Oliva, P.   +6 more
openaire   +9 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source