Results 41 to 50 of about 811,314 (298)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mapping the teaching of honeybee veterinary medicine in the European Union and European Free Trade Area [PDF]

, 2019
Background Honey bee (Apis mellifera) is a very important species for human beings, animals, environmental biodiversity, crop production and economic sustainability in Europe and worldwide. This study investigates whether future veterinarians are trained
Bravo, Ana, De Briyne, Nancy, Iatridou, Despoina, Pohl, Laura, Saunders, Jimmy, Tlak Gajger, Ivana   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

PRIMARY ISOLATION OF NEWCASTLE DISEASE VIRUS IN MDBK CELLINE [PDF]

Journal of Veterinary and Animal Sciences, 1997
Newcastle disease is a dreadful disease of poultry but accurate diagnosis of the disease almost always involves the isolation and characterisation of the virus (Alexander, 1988). For isolation of Newcastle disease virus (NDV) embryonated hens eggs (Beard
Parimal Roy, A.T. Venugopalan, K. Kumanan   +2 more
doaj  

Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. [PDF]

, 2011
Considerable attention has been paid to identifying genetic influences and gene-environment interactions that increase vulnerability to environmental stressors, with promising but inconsistent results.
Bailey, JN, Breidenthal, SE, Fairbanks, LA, Jorgensen, MJ, Kaplan, JR, Laudenslager, ML   +5 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

An integrated Taguchi and response surface methodological approach for the optimization of an HPLC method to determine glimepiride in a supersaturatable self-nanoemulsifying formulation

Saudi Pharmaceutical Journal, 2016
We studied the application of Taguchi orthogonal array (TOA) design during the development of an isocratic stability indicating HPLC method for glimepiride as per TOA design; twenty-seven experiments were conducted by varying six chromatographic factors.
Rajendra Narayan Dash, Habibuddin Mohammed, Touseef Humaira   +2 more
doaj   +1 more source

Honey Bee Viruses, Colony Health, and Antiviral Defense

Proceedings, 2020
Honey bee colony losses are influenced by multiple abiotic and biotic factors, including viruses. To investigate the effects of RNA viruses on honey bees, we infected bees with a model virus (Sindbis-GFP) in the presence or absence of double-stranded RNA
Katie F. Daughenbaugh, Alex J. McMenamin, Laura M. Brutscher, Fenali Parekh, Michelle L. Flenniken   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A character-strengths based coaching intervention to improve wellbeing of rural community health workers in Madhya Pradesh, India: Protocol for a single-blind randomized controlled trial

Contemporary Clinical Trials Communications
Background: There is scarce knowledge on the use of structured positive psychology interventions for reducing work-stress and improving wellbeing of rural community health workers in India, particularly the Accredited Social Health Activists (ASHAs) who ...
Ameya P. Bondre, Azaz Khan, Abhishek Singh, Spriha Singh, Ritu Shrivastava, Narendra Verma, Aashish Ranjan, Jyotsna Agrawal, Seema Mehrotra, Rahul Shidhaye, Anant Bhan, John A. Naslund, Steve D. Hollon, Deepak Tugnawat   +13 more
doaj   +1 more source